Gait Rehabilitation to Treat FastOA

NCT ID: NCT05848622

Last Updated: 2025-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-13

Study Completion Date

2026-05-31

Brief Summary

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The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.

Detailed Description

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Conditions

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Anterior Cruciate Ligament Injuries Post-traumatic Osteoarthritis Knee Osteoarthritis Osteo Arthritis Knee Knee Injuries Cartilage, Articular Gait

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Real-time gait biofeedback (RTGBF)

The RTGBF regimen delivers biofeedback that cues a personalized target to normalize vertical ground reaction force (vGRF) of each limb.

Group Type ACTIVE_COMPARATOR

Real-time gait biofeedback

Intervention Type BEHAVIORAL

The RTGBF interventions will include eighteen step gait training sessions. The intervention will gradually increase to 3,000 steps at the 5th session with 100% feedback. During the remaining sessions, the intervention will include 3,000 steps, but the feedback will be gradually tapered off starting with the 11th session.

Sham real-time gait biofeedback (Sham RTGBF)

The Sham RTGBF regimen will receive biofeedback that cues their habitual step length determined during the accommodation period on the first session of treadmill walking.

Group Type SHAM_COMPARATOR

Sham real-time gait biofeedback

Intervention Type BEHAVIORAL

The Sham RTGBF interventions will include eighteen step gait training sessions. The intervention will gradually increase to 3,000 steps at the 5th session with 100% feedback. During the remaining sessions, the intervention will include 3,000 steps, but the feedback will be gradually tapered off starting with the 11th session.

Interventions

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Real-time gait biofeedback

The RTGBF interventions will include eighteen step gait training sessions. The intervention will gradually increase to 3,000 steps at the 5th session with 100% feedback. During the remaining sessions, the intervention will include 3,000 steps, but the feedback will be gradually tapered off starting with the 11th session.

Intervention Type BEHAVIORAL

Sham real-time gait biofeedback

The Sham RTGBF interventions will include eighteen step gait training sessions. The intervention will gradually increase to 3,000 steps at the 5th session with 100% feedback. During the remaining sessions, the intervention will include 3,000 steps, but the feedback will be gradually tapered off starting with the 11th session.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Have completed all other formal physical therapy
* Are between the ages of 16 and 35
* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6 and 60 months prior to enrollment
* Demonstrate underloading during gait (vGRF- impact peak \<1.12 x BW)

Exclusion Criteria

* A multiple ligament surgery (i.e., PCL)
* A lower extremity fracture (i.e., displaced tibial plateau fracture)
* Knee osteoarthritis
* The participant has a BMI ≥ 36.
Minimum Eligible Age

16 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Arthritis Foundation

OTHER

Sponsor Role collaborator

University of North Carolina, Chapel Hill

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Brian Pietrosimone, PhD

Role: PRINCIPAL_INVESTIGATOR

University of North Carolina, Chapel Hill

Locations

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University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Natalia Favoreto, MS

Role: CONTACT

9199622025

Brian Pietrosimone, PhD

Role: CONTACT

19199623617

Other Identifiers

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21-1489b

Identifier Type: -

Identifier Source: org_study_id

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