Four Mandibular Implant-retained Overdentures in Individuals With Type 2 Diabetes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-04

Study Completion Date

2024-08-05

Brief Summary

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Studies clinically evaluate the long-term outcome of 4 implant attachment-retained mandibular OVDs among patients with high glycemic levels are lacking.

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Detailed Description

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Chronic hyperglycemia is considered as a typical risk-factor that causes soft tissue inflammation and bone loss around natural teeth and implants. One possible explanation for this mechanism is that chronic hyperglycemia has the propensity to increase the levels of accumulated glycation end products (AGEs) in the serum and oral tissues that accelerates the production of proinflammatory cytokines that induce bone destruction around natural teeth and implants. However, it is relevant to indicate that dental implants in chronic hyperglycemia under ideal glycemic conditions can successfully osseointegrate and show predictable outcomes over long durations in both diabetic and non-diabetic patients.

Studies clinically evaluate the long-term outcome of 4 implant attachment-retained mandibular OVDs among patients with high glycemic levels are lacking.

Conditions

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Bone Resorption

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group1 with Haemoglobin A1c ≤6.5%

This group represents a well-controlled type 2 Diabetics mellitus.

Observational study

Intervention Type OTHER

evaluate implant survival, peri-implant outcome of 4 implant retained mandibular OVD after 10 years of function.

Group 2 with Haemoglobin A1c >6.5%

This group represents a poorly controlled type 2 Diabetics mellitus.

Observational study

Intervention Type OTHER

evaluate implant survival, peri-implant outcome of 4 implant retained mandibular OVD after 10 years of function.

Interventions

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Observational study

evaluate implant survival, peri-implant outcome of 4 implant retained mandibular OVD after 10 years of function.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with edentulous maxilla and mandible for at least 12 months.
* Patients have problems with mandibular denture retention and stability.
* Patients with a mandibular bone height measured on a panoramic x-ray between 15 and 25 mm at the mandibular symphysis region.

Exclusion Criteria

* Patients who did not receive implants at the department clinic.
* Patients with more or less than 4 implants in the mandible.
* Patients with well controlled diabetics.
* Patients with relative contraindications, such as a history of parafunctional habits, daily smokers of more than 10 cigarettes, or alcoholism.
* Patients who have previously received head and neck radiation therapy; furthermore, patients receiving intravenous bisphosphonates, chemotherapy, or psychological disorders could jeopardize their cooperation.

Minimum Eligible Age

55 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No