Applied Forces During Neonatal Face Mask Ventilation With Different Face-mask Air Cushion Volumes

NCT ID: NCT06161389

Last Updated: 2024-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-11

Study Completion Date

2023-12-14

Brief Summary

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Positive pressure ventilation (PPV) is the most important intervention in neonatal resuscitation. During PPV, it is important to hold the face-mask with care, as applying excessive pressure could cause injury to the infant, while insufficient pressure could be a contributor of mask leak and reduced effective ventilation. Application of positive pressure to face structures may trigger a vagally mediated reflex via the trigeminal nerve that innervates the skin of the face leading to apnoea and a decrease in heart rate (TCR, trigeminal-cardiac reflex).

In neonatal manikins, ventilation with a partially or fully inflated face mask does not seem to result in differences in mask leak. The force exerted by providers to improve mask seal might result in pressure lesions and in the elicitation of the trigeminal-cardiac reflex. However, information about the applied forces is unknown.

Detailed Description

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Conditions

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Positive Pressure Ventilation Preterm Infants Apnea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Partially inflated mask

Participants will be invited to administer positive pressure ventilation by using a partially inflated mask in a neonatal manikin

Group Type EXPERIMENTAL

Partially inflated mask

Intervention Type DEVICE

Manikin ventilation with a partially inflated mask

Fully inflated mask

Participants will be invited to administer positive pressure ventilation by using a fully inflated mask in a neonatal manikin

Group Type ACTIVE_COMPARATOR

Fully inflated mask

Intervention Type DEVICE

Manikin ventilation with a fully inflated mask

Interventions

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Partially inflated mask

Manikin ventilation with a partially inflated mask

Intervention Type DEVICE

Fully inflated mask

Manikin ventilation with a fully inflated mask

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Level III NICU consultants and pediatric residents

Exclusion Criteria

* None
Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital Padova

OTHER

Sponsor Role lead

Responsible Party

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Daniele Trevisanuto

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Azienda Ospedaliera di Padova, University of Padova

Padua, , Italy

Site Status

Countries

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Italy

References

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Madar J, Roehr CC, Ainsworth S, Ersdal H, Morley C, Rudiger M, Skare C, Szczapa T, Te Pas A, Trevisanuto D, Urlesberger B, Wilkinson D, Wyllie JP. European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth. Resuscitation. 2021 Apr;161:291-326. doi: 10.1016/j.resuscitation.2021.02.014. Epub 2021 Mar 24.

Reference Type BACKGROUND
PMID: 33773829 (View on PubMed)

Schilleman K, Witlox RS, Lopriore E, Morley CJ, Walther FJ, te Pas AB. Leak and obstruction with mask ventilation during simulated neonatal resuscitation. Arch Dis Child Fetal Neonatal Ed. 2010 Nov;95(6):F398-402. doi: 10.1136/adc.2009.182162. Epub 2010 Jun 30.

Reference Type BACKGROUND
PMID: 20591880 (View on PubMed)

van Vonderen JJ, Kleijn TA, Schilleman K, Walther FJ, Hooper SB, te Pas AB. Compressive force applied to a manikin's head during mask ventilation. Arch Dis Child Fetal Neonatal Ed. 2012 Jul;97(4):F254-8. doi: 10.1136/archdischild-2011-300336. Epub 2011 Dec 5.

Reference Type BACKGROUND
PMID: 22147285 (View on PubMed)

Cavallin F, Sala C, Maglio S, Bua B, Villani PE, Menciassi A, Tognarelli S, Trevisanuto D. Applied forces with direct versus indirect laryngoscopy in neonatal intubation: a randomized crossover mannequin study. Can J Anaesth. 2023 May;70(5):861-868. doi: 10.1007/s12630-023-02402-9. Epub 2023 Feb 14.

Reference Type BACKGROUND
PMID: 36788198 (View on PubMed)

Other Identifiers

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NEOUNIPD3(2023)

Identifier Type: -

Identifier Source: org_study_id

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