Resistance Training on Growth Factors

NCT ID: NCT06114550

Last Updated: 2024-02-01

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-02-27
• Study Completion Date: 2024-04-07

Brief Summary

The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:

1. Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.

2. whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.

Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).

Researchers will compare the training effects of two different training on these growth factors.

Conditions

Cognitive Function

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

High-intensity resistance training group (HIRT)

All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set.

Group Type: EXPERIMENTAL

High intensity resistance training

Intervention Type: OTHER

The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.

low-intensity resistance training group (LIRT)

All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order.

Group Type: EXPERIMENTAL

Low intensity resistance training

Intervention Type: OTHER

For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

Interventions

High intensity resistance training

The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.

Intervention Type: OTHER

Low intensity resistance training

For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age between 18 to 30 years
• no experiencing musculoskeletal disorders or sports injuries
• had not participated any regular aerobic endurance or resistance training with in the previous half years
• no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
• good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)

Exclusion Criteria

• experiencing musculoskeletal disorders or sports injuries in recent 1 month
• had regular resistance training exercise
• intake any supplementary(drug and hormone)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Air Force Military Medical University, China

OTHER

Sponsor Role: lead

Responsible Party

Chongwen Zuo

Doctoral

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

chongwen zuo, Doctoral

Role: PRINCIPAL_INVESTIGATOR

Air Force Medical Center of Chinese PLA

Central Contacts

Chongwen Zuo, Doctoral

Role: CONTACT

zuochongwen@cupes.edu.cn

+86 18810716505

Other Identifiers

zuochongwen

Identifier Type: -

Identifier Source: org_study_id