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NCT02458443

Isometric Handgrip Exercise for Blood Pressure Management

NCT ID: NCT02458443

Last Updated: 2020-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2016-12-31

Brief Summary

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Recent meta-analyses suggest isometric resistance training (IRT) may be superior to aerobic exercise for lowering blood pressure. The investigators intend to conduct the largest, longest, prospective, double-blind randomized controlled trial using isometric resistance training to reduce blood pressure to reduce hypertension.

Detailed Description

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We are looking to assess the effect of isometric exercise on ambulatory blood pressure in participants aged 40-70 years who are either pre- or mild hypertensive; either un-medicated or taking medication to control their blood pressure. Our secondary aims are to examine whether the size of blood pressure change is different in those people taking or not taking anti-hypertensive medication, to determine the anti-hypertensive mechanism to IRT, and to establish rate of de-training effects after participants have ceased IRT.

Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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IHG 5% Un-medicated

Participants with high blood pressure (greater than 120/80) who are not medicated for blood pressure control will conduct isometric handgrip (IHG) exercise at 5% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Group Type SHAM_COMPARATOR

Isometric resistance training

Intervention Type OTHER

Isometric handgrip exercise using a hand dynamometer

IHG 5% BB

Participants with high blood pressure (greater than 120/80) who are currently taking beta blockers for blood pressure control will conduct isometric handgrip exercise at 5% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Group Type SHAM_COMPARATOR

Isometric resistance training

Intervention Type OTHER

Isometric handgrip exercise using a hand dynamometer

IHG 30% Un-medicated

Participants with high blood pressure (greater than 120/80) who are not medicated for blood pressure control will conduct isometric handgrip exercise at 30% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Group Type EXPERIMENTAL

Isometric resistance training

Intervention Type OTHER

Isometric handgrip exercise using a hand dynamometer

IHG 30% BB

Participants with high blood pressure (greater than 120/80) who are currently taking beta blockers for blood pressure control will conduct isometric handgrip exercise at 30% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Group Type EXPERIMENTAL

Isometric resistance training

Intervention Type OTHER

Isometric handgrip exercise using a hand dynamometer

Interventions

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Isometric resistance training

Isometric handgrip exercise using a hand dynamometer

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Blood pressure above 120/80 currently not taking anti-hypertensive medications whose doctor has suggested would benefit from exercise; and
* people currently taking beta blockers for blood pressure management.

Exclusion Criteria

* Younger than 30yrs and older than 70 yrs;
* unable to voluntary participate;
* unable to participate under doctor's recommendation;
* smokers;
* arthritis or carpal tunnel which may be aggravated with handgrip exercise;
* known cardiovascular disease (angina) and the following co-morbid conditions:

* obesity,
* insulin resistance,
* depression,
* mobility impairment,
* sleep apnoea,
* fatty liver disease or
* renal disease

Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of New England, Australia

OTHER

Sponsor Role lead

Responsible Party

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Deb Carlson

Sponsor-Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Neil Smart, PhD

Role: PRINCIPAL_INVESTIGATOR

University of New England

Locations

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UNE Exercise Physiology Lab

Armidale, New South Wales, Australia

Site Status

Countries

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Australia

References

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Carlson DJ, Dieberg G, Hess NC, Millar PJ, Smart NA. Isometric exercise training for blood pressure management: a systematic review and meta-analysis. Mayo Clin Proc. 2014 Mar;89(3):327-34. doi: 10.1016/j.mayocp.2013.10.030.

Reference Type BACKGROUND

PMID: 24582191 (View on PubMed)

Other Identifiers

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UNewEngland

Identifier Type: -

Identifier Source: org_study_id