Genetic Factors and CP Pregnancy Outcomes

NCT ID: NCT06055595

Last Updated: 2023-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2024-12-31

Brief Summary

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To explore the impact of chronic pancreatitis (CP) susceptibility genes on pregnancy outcomes.

Detailed Description

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The goal of this observational study is to explore the impact of CP susceptibility genes (SPINK1, PRSS1, CTRC, CFTR) on pregnancy outcomes (including both maternal and fetal outcomes) in a large Chinese cohort. Participants will be asked to provide their pregnancy-related data.

Conditions

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Chronic Pancreatitis Genetic Mutation Pregnancy Related

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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genetic sequencing

sequencing the susceptibility genes for CP, including serine protease inhibitor Kazal type 1, cationic trypsinogen, cystic fibrosis transmembrane conductance regulator, chymotrypsin C, etc.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* female patients with a diagnosis of chronic pancreatitis
* have known genetic backgrounds and pregnancy history
* agree to join the study and provide informed consent

Exclusion Criteria

* patients without documented pregnancy
* patients who denied to provide pregnancy-related information, or with incomplete pregnancy characteristics and/or outcomes
* patients with other autoimmune comorbidities that might influence pregnancy outcomes, such as systemic lupus erythematosus, autoimmune thyroid diseases, etc
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Changhai Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Zhuan Liao

Role: PRINCIPAL_INVESTIGATOR

Changhai Hospital

Locations

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Changhai Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

References

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Wu D, Ru N, Wang YC, Ma GX, Shi TY, Xiong SH, You AJ, Wang L, Hu LH, Li ZS, Zou WB, Liao Z. Genetic Factors Associated With Adverse Pregnancy Outcomes in Chronic Pancreatitis. Clin Transl Gastroenterol. 2024 Apr 1;15(4):e00691. doi: 10.14309/ctg.0000000000000691.

Reference Type DERIVED
PMID: 38334943 (View on PubMed)

Other Identifiers

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CP-gene-pregnancy outcomes

Identifier Type: -

Identifier Source: org_study_id

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