Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder
NCT ID: NCT06045650
Last Updated: 2024-05-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
92 participants
OBSERVATIONAL
2024-06-01
2025-09-01
Brief Summary
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Primary Hypothesis (H1):
There is a significant difference in trust-related behavior as measured by oxytocin (OXT) levels between borderline personality disorder (BPD) patients and healthy controls.
Secondary Hypotheses:
H2: The trust-related behavior in BPD patients is significantly influenced by their level of emotional sensitivity. Specifically, higher emotional sensitivity in BPD patients is associated with lower trust-related behavior and vice-versa.
H3: There is a significant correlation between trust-related behavior and childhood trauma in BPD patients. BPD patients with higher levels of reported childhood trauma will exhibit lower trust-related behavior compared to those with lower levels of trauma.
H4: Trust-related behavior in BPD patients varies depending on their attachment styles. Specifically, BPD patients with insecure attachment styles will exhibit lower trust-related behavior compared to those with secure attachment styles.
H5: There is a significant correlation between trust-related behavior and BPD severity. Patients with more severe BPD symptoms will exhibit lower trust-related behavior compared to those with less severe symptoms.
H6: The levels of OXT in BPD patients will significantly correlate with their reported levels of emotional sensitivity, childhood trauma, attachment styles, and BPD severity.
These hypotheses aim to address the complexities surrounding the modulation of trust-related behavior by oxytocin in BPD patients, taking into account various factors like emotional sensitivity, childhood adversity, attachment styles, and BPD severity. By testing these hypotheses, the study aims to provide a comprehensive understanding of the interplay between these factors in influencing trust-related behavior in BPD patients.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Cases
Participants with borderline personality disorder who meet the inclusion criteria
baseline serum oxytocin levels
Both cases and controls will be assessed for their baseline serum oxytocin levels
Emotional Sensitivity test
To assess the level of emotional sensitivity in the participant
Neuro-economical game
A game played to assess the trust-index of participants
Childhood Trauma Questionnaire
to assess childhood trauma score
Relationships Questionnaire
to assess attachment type
demographic questionnaire
To obtain basic data on demographics
Controls
Participants without borderline personality disorder, who meet the inclusion criteria
baseline serum oxytocin levels
Both cases and controls will be assessed for their baseline serum oxytocin levels
Emotional Sensitivity test
To assess the level of emotional sensitivity in the participant
Neuro-economical game
A game played to assess the trust-index of participants
Childhood Trauma Questionnaire
to assess childhood trauma score
Relationships Questionnaire
to assess attachment type
demographic questionnaire
To obtain basic data on demographics
Interventions
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baseline serum oxytocin levels
Both cases and controls will be assessed for their baseline serum oxytocin levels
Emotional Sensitivity test
To assess the level of emotional sensitivity in the participant
Neuro-economical game
A game played to assess the trust-index of participants
Childhood Trauma Questionnaire
to assess childhood trauma score
Relationships Questionnaire
to assess attachment type
demographic questionnaire
To obtain basic data on demographics
Eligibility Criteria
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Inclusion Criteria
* controls will be age, gender matched individuals without any psychiatric/mental health concerns
Exclusion Criteria
* for controls: MacLEan screening instrument for BPD will be used at the time of screening to exclude BPD diagnosis in controls
18 Years
ALL
Yes
Sponsors
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State University of New York - Upstate Medical University
OTHER
Responsible Party
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Luba Leontieva
M.D./PhD, Director of Inpatient Unit, Associate Professor, Department of Psychiatry and Behavioral Sciences
Locations
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SUNY Upstate Medical University
Syracuse, New York, United States
Countries
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Facility Contacts
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Other Identifiers
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2060971
Identifier Type: -
Identifier Source: org_study_id
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