Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2018-07-31

Brief Summary

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The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.

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Detailed Description

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To investigate whether oxytocin (24IU) might interact with female sex hormone in modulating the rewarding effect of compliment to women in a romantic context.

The study employs a double-blind, within-subject, placebo-control design. Women will be administered with the same drug twice (oxytocin or placebo) respectively the fertile and luteal phase followed by a MRI scanning. During fMRI participants will rate men's attraction based on their facial pictures of average attractiveness associated with compliments of different combination of form and topic. Each male face will be paired with two sentences of the same kind. After the fMRI participants will recall the judgment followed by a memory test during which they have to indicate whether the they have seen the face during scanning (old) or whether it is an unknown face (new).

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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oxytocin fertility

intranasal oxytocin administration (24IU) in women's fertility phase (LH\>40 mIU/ml)

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

placebos fertility

intranasal placebo administration (24IU) in women's fertility phase (LH\>40 mIU/ml)

Group Type PLACEBO_COMPARATOR

Placebos

Intervention Type DRUG

oxytocin luteal

intranasal oxytocin administration (24IU) in women's luteal phase (LH\<30 mIU/ml)

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

placebos luteal

intranasal placebos administration (24IU) in women's luteal phase (LH\<30 mIU/ml)

Group Type PLACEBO_COMPARATOR

Placebos

Intervention Type DRUG

Interventions

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Oxytocin

Intervention Type DRUG

Placebos

Intervention Type DRUG

Other Intervention Names

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oxytocin treatment placebo control

Eligibility Criteria

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Inclusion Criteria

* Single in the past 3 months
* Healthy subjects with regular menstrual cycle

Exclusion Criteria

* Pregnant, menstruating, taking oral contraceptives
* metal implanted, with tatoo, or hair dyed within 6 months
* participated in another intranasal experiment within 6 months
* with a history of past or current psychiatric or neurological disorder

Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes