Sex- and Context-dependent Effects of Oxytocin on Social Reward Processing

NCT ID: NCT03085628

Last Updated: 2018-02-07

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 252 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-07-31
• Study Completion Date: 2018-12-31

Brief Summary

The aim of the present study is to examine whether the neuropeptide oxytocin (OXT) influences social reward processing and whether the effects are context- and sex-dependent.

Detailed Description

In a double-blind, randomized, placebo-controlled, between-subject design healthy volunteers will receive either oxytocin or placebo nasal spray (40IU in 10 puffs).

Subjects will come to the experiment in pairs (two friends of the same sex). 45 min after drug administration, the two subjects will simultaneously undergo a social reward task - during the task, functional magnetic resonance imaging (fMRI) data will be acquired from one of them. During the social reward task subjects will be asked to rate the valence and arousal of emotional pictures in three different conditions: alone, share with a stranger and share with their friend.

Before treatment, subjects will complete a range of validated questionnaires to control for potential confounders, such as level of depression (assessed using the BDI) and to explore associations between relevant personality factors and treatment effects, such as adult attachment style (assessed using the AAS).

Conditions

Mental Health Wellness 1; Social Behavior; Emotion

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Oxytocin

Oxytoxin nasal spray

Group Type: EXPERIMENTAL

Oxytocin

Intervention Type: DRUG

40IU

Placebo

Placebo nasal spray

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

40IU

Interventions

Oxytocin

40IU

Intervention Type: DRUG

Placebo

40IU

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorder, right-handed, had normal or corrected-to normal vision.

Exclusion Criteria

• self-reported medication use, substance abuse, and presence of medical or psychiatric disorders

• Minimum Eligible Age: 17 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Electronic Science and Technology of China

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

school of life science and technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Keith Kendrick, Dr

Role: CONTACT

kkendrick@uestc.edu.cn

Benjamin Becker, Dr

Role: CONTACT

ben_becker@gmx.de

Facility Contacts

Qin Li, Master

Role: primary

helenlee@uestc.edu.cn

References

Ma X, Zhao W, Luo R, Zhou F, Geng Y, Xu L, Gao Z, Zheng X, Becker B, Kendrick KM. Sex- and context-dependent effects of oxytocin on social sharing. Neuroimage. 2018 Dec;183:62-72. doi: 10.1016/j.neuroimage.2018.08.004. Epub 2018 Aug 4.

Reference Type: DERIVED

PMID: 30086408 (View on PubMed)

Other Identifiers

UESTC-neuSCAN-08

Identifier Type: -

Identifier Source: org_study_id