Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis

NCT ID: NCT06006663

Last Updated: 2023-08-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-26

Study Completion Date

2023-12-10

Brief Summary

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this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.

Detailed Description

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we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .

samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.

bacterial reduction will be determined and comparision will be made .

Conditions

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Effective Intracanal Medicaments Against Enterococcus Faecalis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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group 1

ibuprofen as intracanal medicament

Group Type ACTIVE_COMPARATOR

Ibuprofen 400 mg.

Intervention Type DRUG

synthetic intracanal medicament

group 2

modified triple antibiotic paste as intracanal medicament

Group Type ACTIVE_COMPARATOR

modified triple antibiotic paste

Intervention Type DRUG

synthetic intracanal medicament

group 3

curcumin as intracanal medicament

Group Type ACTIVE_COMPARATOR

curcumin

Intervention Type DIETARY_SUPPLEMENT

herbal intracanal medicament

group 4

olive leaves as intracanal medicament

Group Type ACTIVE_COMPARATOR

olive leaves extract

Intervention Type DIETARY_SUPPLEMENT

herbal intracanal medicament

Interventions

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Ibuprofen 400 mg.

synthetic intracanal medicament

Intervention Type DRUG

modified triple antibiotic paste

synthetic intracanal medicament

Intervention Type DRUG

curcumin

herbal intracanal medicament

Intervention Type DIETARY_SUPPLEMENT

olive leaves extract

herbal intracanal medicament

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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clindamycin, ciprofloxacin and metronidazole

Eligibility Criteria

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Inclusion Criteria

* Single rooted teeth.
* Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
* Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.

Exclusion Criteria

* • Teeth with fractures of the crown or root.

* Teeth with periodontal pocket deeper than 4mm.
* Teeth have procedural error like ledge, broken instrument, or perforation.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Alaa Essam Ahmed Abo Laimon

Demonstrator , Endodontic department,Faculty of dentistry,Tanta university

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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alaa essam abo laimon, demonstrator at university

Role: CONTACT

01005690958

Other Identifiers

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eliminations of E.faecalis

Identifier Type: -

Identifier Source: org_study_id

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