Streptococcus Mutans Cariogenicity by Real-time PCR in High Caries Risk Patients
NCT ID: NCT04566120
Last Updated: 2023-12-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
37 participants
INTERVENTIONAL
2021-01-01
2023-02-01
Brief Summary
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Detailed Description
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All patients will be instructed not to have breakfast and to refrain any oral hygiene measures on the day of sample collection to avoid the influence of food consumption and contamination on the composition of saliva. The patient will sit in an erect position on the dental chair and will be given paraffin block to chew. The stimulated saliva will be collected after 2 minutes of paraffin chewing in sterile containers held near the mouth. The containers will be properly labeled. The study will be carried over a period of one month, the saliva samples for each patient will be collected on the first dental visit. These samples will be then sent to the laboratory for microbiological assessment. Patients will be provided with mouthwashes according to the tested groups and they will be instructed to use it 2 times per day for 1 minute each time and no eating or drinking permitted for a minimum of 30 minutes post rinsing. Each patient will be given the same instructions with respect to oral hygiene measures. They will be advised to continue on same diet and will be instructed not to change their dietary habits. Patients will come after 2 weeks for salivary samples collection and samples will be sent to the laboratory for microbiological assessment. After treatment continuity for another 2 weeks, patients will come for the last visit to collect the salivary samples which will be sent to the laboratory for microbiological assessment.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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Cinnamon extract mouthwash
Participants will be exposed to cinnamon extract mouthwash and will be instructed to use 10 ml of cinnamon extract mouthwash 2 times per day for 1 minute; such a regimen will be continued for one month.
cinnamon extract mouthwash
cinnamon extract mouthwash
Chlorohexidine based mouthwash
Participants will be exposed to chlorohexidine based mouthwash. and will be instructed to use 10 ml of 0.12% chlorhexidine based mouthwash 2 times per day for 1 minute; such a regimen will be continued for one month.
chlorohexidine based mouthwash
chlorohexidine based mouthwash
Interventions
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cinnamon extract mouthwash
cinnamon extract mouthwash
chlorohexidine based mouthwash
chlorohexidine based mouthwash
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age range 20-50 years
* High caries risk patients according to ADA caries risk assessment model.
* High plaque index (\>score 2)
* Non-smoking patients.
* Patients with normal salivary rate (0.3-0.4 ml/min).
Exclusion Criteria
* Participants with low caries risk.
* Patients with severe or active periodontal disease.
* Participants with a history of allergy to any of the drugs or chemicals used in the study.
* Patients on any antibiotics during the past month
* Smoking patients.
* Patients with abnormal salivary rate.
* Pregnant female patients
20 Years
50 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Mostafa Mahmoud Mohamed Kamel El-Ghazali
Principle Investigator
Principal Investigators
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Mostafa El-Ghazali
Role: PRINCIPAL_INVESTIGATOR
Assistant Lecturer
Locations
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Cairo Uniuversity
Giza, , Egypt
Countries
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Other Identifiers
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oper131
Identifier Type: -
Identifier Source: org_study_id