Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

488 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-15

Study Completion Date

2025-06-14

Brief Summary

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Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.

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Detailed Description

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Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.

Conditions

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Aging Dementia Alzheimers Parkinson Disease Dementia Frontotemporal Depression in Old Age

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Neurocognitive disorder (NCD)

The NCD patients are defined with a chronological age over 60 years and a Montreal Cognitive Assessment (MoCA) total score between 22 and 26.

Transcranial Magnetic Stimulation

Intervention Type DEVICE

One time for each day, lasting for three weeks.

Interventions

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Transcranial Magnetic Stimulation

One time for each day, lasting for three weeks.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Right-handed as assessed by the Edinburgh Inventory
* Able to attend TMS interventions
* Consent
* Independent in daily life activities

Exclusion Criteria

* Uncorrected visual or auditive deficits not allowing the realization of the test
* Evolutive disease (such as cancer)
* Neurological or psychiatric antecedent
* Counter-indication to MRI

Minimum Eligible Age

60 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes