Clinical and Microbiological Approach in Orthopedic Treatment of Patients When Choosing a Structural Material

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-01

Study Completion Date

2025-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Today, there is a wide range of structural materials on the market, different in chemical, physical and biological properties, and information about them is very often limited only by the manufacturer's instructions, which allows to determine, at best, only the scope. In this regard, there are difficulties in choosing the optimal material for this particular situation, since without a thorough approach to studying the properties of the main materials used in dentistry, it seems difficult to provide high-quality dental care, the result of which is functional usefulness, aesthetics and durability.The problem of an individual approach to the choice of structural material from the standpoint of personalized medicine is even less studied - there are no data in the literature on the role of normal and pathogenic microflora in the development of destructive changes in structures and the development of complications, taking into account a personalized approach when analyzing the composition of the microbiota of the oral cavity, biochemical parameters of the oral fluid, blood depending on the material from which the structure is made.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Assessment of the Effects of Different Implant Abutment Occluding Materials on Dental Implant Health Parameters and Microbiology

NCT02625597

Peri-Implantitis Dental Implant Failed Dental Implant Failure Nos

COMPLETED NA

The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health

NCT06378502

Antibiotic

NOT_YET_RECRUITING PHASE4

Antibiotic Regimen for Dental Implants Cases

NCT05900297

Dental Implant Infection

UNKNOWN

Maintenance Protocol for Implant Supported Hybrid Prosthesis.

NCT05482490

Implant Infection

UNKNOWN NA

Microbiome Development in the Early Healing of Osseointegrated Implants

NCT05941663

Microbiota Dental Implants

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Relevance of the topic Today, there is a wide range of structural materials on the market, different in chemical, physical and biological properties, and information about them is very often limited only by the manufacturer's instructions, which allows to determine, at best, only the scope. In this regard, there are difficulties in choosing the optimal material for this particular situation, since without a thorough approach to studying the properties of the main materials used in dentistry, it seems difficult to provide high-quality dental care, the result of which is functional usefulness, aesthetics and durability.The problem of an individual approach to the choice of structural material from the standpoint of personalized medicine is even less studied - there are no data in the literature on the role of normal and pathogenic microflora in the development of destructive changes in structures and the development of complications, taking into account a personalized approach when analyzing the composition of the microbiota of the oral cavity, biochemical parameters of the oral fluid, blood depending on the material from which the structure is made.

Purpose of the study Improving the efficiency of orthopedic treatment of patients with dentition defects based on a clinical and microbiological personalized approach

Research objectives:

1. Conduct an analysis of the need for fixed orthopedic structures among the population at the regional level
2. Assess the influence of the material chosen for prosthetics on the species diversity of oral microorganisms
3. To study the dependence of the degree of microbial adhesion on the nature of the material and manufacturing technology on various fixed orthopedic structures
4. Develop and implement a method for preventing complications in patients with prosthetics using various structural materials
5. Conduct a comparative assessment of the orthopedic treatment of patients using the developed method for the prevention of complications and the traditional method based on clinical and functional research methods

Material (object) of research:

The clinical part of the study is carried out at the Department of Orthopedic of dentistry of Samara State Medical University on the basis of GBUZ SO SSP No. 3 g.o. Samara. To solve the tasks of the study, an analysis of the clinical observation of patients. Planned orthopedic treatment 20 patients with zirconia 20 e-max patients 20 patients Cobalt-chromium alloy 20 patients Biological material will be taken from each patient before the delivered structure and after 1 month of the structure's arrival in the oral cavity

Research methods:

Clinical

* hygiene indexes
* CPU index Microbiological
* MALDI-ToF mass spectrometry Clinical diagnostic research
* biochemical study of saliva
* biochemical blood test X-ray examination Scientific novelty of the work

1. For the first time, a personalized approach will be developed in the choice of structural material for the manufacture of dentures based on a clinical and microbiological study
2. For the first time, an analysis of the results of treatment and the development of complications will be carried out using the proposed method.
3. For the first time, a cultural study of the composition of microorganisms of the oral mucosa will be carried out, depending on the selected material
4. For the first time, a model of microbiological examination of patients will be scientifically substantiated when choosing a structural material Practical significance

* For the first time, an algorithm for orthopedic treatment will be proposed when choosing a structural material depending on the microbiology of the oral cavity
* For the first time, methods will be proposed for determining the influence of oral microflora on orthopedic structures, taking into account individual characteristics
* For the first time, an algorithm for microbiological examination of patients for prosthetics will be proposed
* For the first time, biomarkers will be proposed to assess the microbial composition of the oral cavity to justify the choice of design

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Oral Microbiota

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.