Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2023-09-15
2024-10-20
Brief Summary
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1. To identify the most common organisms causing dental implant failure.
2. Set an appropriate antibiotic regimen according to the causative organism to limit the antimicrobial resistance by limit the use of antibiotics.
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Detailed Description
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Early implant failure is commonly associated with certain strains of bacteria. The most common bacteria involved are streptococci, anaerobic Gram-positive cocci, and anaerobic Gram-negative rods.Porphyromonas gingivalis and Fusobacterium nucleatum frequently colonize the implant in early and late losses and could therefore be characteristic for implant loss in general.
Thus, the antibiotic to prevent delayed healing of wound should be bactericidal and of low toxicity. Systemic antibiotic prophylaxis has been used to reduce the risk of early implant failure and local infections around dental implants.Antibiotics are one of the most cost-effective, life-saving medicines and contribute to an extended lifespan. Access to antibiotics without a prescription is a driving factor for irrational antibiotic use due to a potential lack of access to proper diagnosis and diagnostic tools. This eventually leads to the development and spread of antibiotic resistance \&it is one of the increasing public health challenges worldwide.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* current antibiotic treatment
* smoking
* acute or chronic oral infection (including ongoing periodontal infection).
18 Years
75 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Salma Mohamed Essam El-din Osman
medical doctor
Central Contacts
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References
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Kochar SP, Reche A, Paul P. The Etiology and Management of Dental Implant Failure: A Review. Cureus. 2022 Oct 19;14(10):e30455. doi: 10.7759/cureus.30455. eCollection 2022 Oct.
Surapaneni H, Yalamanchili PS, Basha MH, Potluri S, Elisetti N, Kiran Kumar MV. Antibiotics in dental implants: A review of literature. J Pharm Bioallied Sci. 2016 Oct;8(Suppl 1):S28-S31. doi: 10.4103/0975-7406.191961.
Machowska A, Stalsby Lundborg C. Drivers of Irrational Use of Antibiotics in Europe. Int J Environ Res Public Health. 2018 Dec 23;16(1):27. doi: 10.3390/ijerph16010027.
Momand P, Becktor JP, Naimi-Akbar A, Tobin G, Gotrick B. Effect of antibiotic prophylaxis in dental implant surgery: A multicenter placebo-controlled double-blinded randomized clinical trial. Clin Implant Dent Relat Res. 2022 Feb;24(1):116-124. doi: 10.1111/cid.13068. Epub 2022 Jan 24.
Korsch M, Marten SM, Stoll D, Prechtl C, Dotsch A. Microbiological findings in early and late implant loss: an observational clinical case-controlled study. BMC Oral Health. 2021 Mar 11;21(1):112. doi: 10.1186/s12903-021-01439-w.
Bernabeu-Mira JC, Penarrocha-Diago M, Penarrocha-Oltra D. Prescription of Antibiotic Prophylaxis for Dental Implant Surgery in Healthy Patients: A Systematic Review of Survey-Based Studies. Front Pharmacol. 2021 Feb 10;11:588333. doi: 10.3389/fphar.2020.588333. eCollection 2020.
Antwi AN, Stewart A, Crosbie M. Fighting antibiotic resistance: a narrative review of public knowledge, attitudes, and perceptions of antibiotics use. Perspect Public Health. 2020 Nov;140(6):338-350. doi: 10.1177/1757913920921209. Epub 2020 Jun 9.
Pyysalo M, Helminen M, Antalainen AK, Sandor GK, Wolff J. Antibiotic prophylaxis patterns of Finnish dentists performing dental implant surgery. Acta Odontol Scand. 2014 Nov;72(8):806-10. doi: 10.3109/00016357.2014.913194. Epub 2014 May 5.
Mombelli A, van Oosten MA, Schurch E Jr, Land NP. The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol. 1987 Dec;2(4):145-51. doi: 10.1111/j.1399-302x.1987.tb00298.x. No abstract available.
Other Identifiers
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antibiotic for dental implants
Identifier Type: -
Identifier Source: org_study_id
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