Relationship Between Porphyromonas Gingivalis and Obesity in Patients With Periodontitis

NCT ID: NCT05942703

Last Updated: 2023-07-12

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 311 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-12-05
• Study Completion Date: 2024-12-30

Brief Summary

Obesity is recognized as a major public health problem. Recent research suggests the involvement of the gut microbiota in the development of obesity. Indeed, obese people are characterized by a dysbiotic intestinal microbiota. Periodontitis are chronic inflammatory oral pathologies linked to an imbalance between the bacterial etiological factor, oral dysbiosis, and the host's immune defenses.They lead to the destruction of the supporting tissues of the tooth and an apical migration of the periodontal attachment system, thus leading to the formation of the pathognomonic entity of the disease, the periodontal pocket.the presence of bacteria of oral origin such as Porphyromonas gingivalis (Pg) has been demonstrated in the adipose tissue of obese patients inducing a chronic low-grade inflammatory response by macrophages which leads to the proliferation of adipocyte precursors predisposing to obesity. The main objective is to assess the average amount of Porphyromonas gingivalis (Pg) in the saliva of obese people (BMI ≥ 30) with periodontitis.

Detailed Description

Obesity is recognized as a major public health problem. Recent research suggests the involvement of the gut microbiota in the development of obesity. Indeed, obese people are characterized by a dysbiotic intestinal microbiota. Periodontitis are chronic inflammatory oral pathologies linked to an imbalance between the bacterial etiological factor, oral dysbiosis, and the host's immune defenses.They lead to the destruction of the supporting tissues of the tooth and an apical migration of the periodontal attachment system, thus leading to the formation of the pathognomonic entity of the disease, the periodontal pocket.the presence of bacteria of oral origin such as Porphyromonas gingivalis (Pg) has been demonstrated in the adipose tissue of obese patients inducing a chronic low-grade inflammatory response by macrophages which leads to the proliferation of adipocyte precursors predisposing to obesity. The main objective is to assess the average amount of Porphyromonas gingivalis (Pg) in the saliva of obese people (BMI ≥ 30) with periodontitis.This study is a comparative cross-sectional non-interventional study with retrospective and prospective and consecutive recruitment of participants.

Prospective patient recruitment:

During the patient's visit to the periodontology department, if the patient has periodontitis and has given his non-objection, he will be included in the study. A routine check-up in odontology will then be carried out: complete medical questionnaire (general, hygiene and dietetics), clinical examination (visual examination and statement of periodontal indices), radiological examination. Samples of saliva and periodontal plaque, conventionally taken in current dental surgery practice in the periodontal management of patients, will be used to carry out bacterial assays. CThe saliva samples, which are part of the usual treatment, will be carried out before and after the non-surgical periodontal treatment.

Conditions

Obesity

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

obese patients

Patients with a body mass index superior or equal at 30 and with a periodontitis

saliva samples

Intervention Type: OTHER

Saliva samples, which are part of the usual treatment, will be carried out before and after the non-surgical periodontal treatment

non-obese (BMI<30) patients

Patients with a body mass index inferior at 30 with a periodontitis

saliva samples

Intervention Type: OTHER

Saliva samples, which are part of the usual treatment, will be carried out before and after the non-surgical periodontal treatment

Interventions

saliva samples

Saliva samples, which are part of the usual treatment, will be carried out before and after the non-surgical periodontal treatment

Intervention Type: OTHER

Other Intervention Names

periodontal plaque samples

Eligibility Criteria

Inclusion Criteria

• over 18 years old
• having periodontitis
• able to receive information on the course of the study and to understand the information form to participate in the study.
• having given their non-objection to participate in the study

Exclusion Criteria

• Having taken antibiotics, prebiotics or probiotics in the month prior to inclusion
• During pregnancy or breastfeeding
• With a history of oral surgery in the month prior to inclusion
• At risk of infection (existence of one or more known chronic infectious diseases)
• Suffering from a general pathology contraindicating the performance of diagnostic procedures such as periodontal probing (patients at high risk of infective endocarditis according to the French National Agency for the Safety of Medicines and Products of Health ANSM)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Toulouse

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sara LAURENCIN, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

UHToulouse

Toulouse, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Sara LAURENCIN, MD

Role: CONTACT

laurencin.s@chu-toulouse.fr

0561344473 ext. +33

Cathy NABET, Pr

Role: CONTACT

catherine.nabet@univ-tlse3.fr

Facility Contacts

Sara LAURENCIN

Role: primary

olivier.i@chu-toulouse.fr

+33561777051

Other Identifiers

RC31/20/0478

Identifier Type: -

Identifier Source: org_study_id