Evaluation of the Impact of an Expert Opinion During the Management of Patients With Severe Bleeding on Oral Anticoagulants.

NCT ID: NCT05928091

Last Updated: 2025-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

1000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-16

Study Completion Date

2027-12-31

Brief Summary

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The goal of this randomized clinical trial is to evaluate the impact of an expert opinion during the management of patients with severe bleeding on oral anticoagulants. The main question it aims to answer is :

• Does an expert help of decision during the management of patients with severe bleeding is superior to classic management ? The centers will be randomized in one of the two groups : control group and interventional group.

Patients will be followed for 3 months. At their inclusion they will be managed in conformity of the randomisation of their center.

They will be followed at hour 0 + 6 , H0+24 and at the end of hospitalization. After 3 months, they will be called to assess the occurrence of thrombotic events ou hemorrhage complications.

Researchers will compare the classic management versus the management with an expert opinion to see if the expert opinion is superior to classic management.

Detailed Description

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Conditions

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Hemorrhage

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Centers will be randomized in two arms :

* control group : each center will manage hemorrhage of participation as they usually did
* interventional group : management of hemorrhage will be guided by the expert team
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control group

Doctors will manage bleeding as usual.

Group Type NO_INTERVENTION

No interventions assigned to this group

Experimental group

Investigators will call a phone number, and an expert will guide them to manage the bleeding.

Group Type EXPERIMENTAL

Phone call to an expert team

Intervention Type OTHER

Patients will be treated as the expert said when the investigator called him

Interventions

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Phone call to an expert team

Patients will be treated as the expert said when the investigator called him

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Major patient treated with oral anticoagulants, admitted in an emergency department
* For suspected major bleeding defined according to the criteria of the International Society of Thrombosis and Haemostasis
* Able to give informed consent to participate in research or, in the event of an emergency, to take charge of a reference person
* Affiliated to a Social Security scheme.

Exclusion Criteria

* Pregnant or breastfeeding women
* Patient under guardianship, curatorship or safeguard of justice
* Administration within the last 24 hours of parenteral anticoagulant.
* Refusal to participate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Clermont-Ferrand

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Fares MOUSTAFA

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Clermont-Ferrand

Locations

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CH Aurillac

Aurillac, , France

Site Status RECRUITING

CHU de Clermont-Ferrand

Clermont-Ferrand, , France

Site Status RECRUITING

CHU Grenoble

Grenoble, , France

Site Status RECRUITING

CH Le Puy

Le Puy-en-Velay, , France

Site Status RECRUITING

Hospice civils de Lyon

Lyon, , France

Site Status RECRUITING

CH de Montbrison

Montbrison, , France

Site Status NOT_YET_RECRUITING

CH Montluçon

Montluçon, , France

Site Status NOT_YET_RECRUITING

CH de Moulins

Moulins, , France

Site Status RECRUITING

CHU de Nice

Nice, , France

Site Status NOT_YET_RECRUITING

CHR Orléans

Orléans, , France

Site Status RECRUITING

La Pitié-Salpétrière

Paris, , France

Site Status NOT_YET_RECRUITING

CHU de Saint-Etienne

Saint-Etienne, , France

Site Status NOT_YET_RECRUITING

CHU de Toulouse

Toulouse, , France

Site Status NOT_YET_RECRUITING

CHU Tours

Tours, , France

Site Status RECRUITING

CH de Vichy

Vichy, , France

Site Status NOT_YET_RECRUITING

Countries

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France

Central Contacts

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Lise LACLAUTRE

Role: CONTACT

+33473754963

Facility Contacts

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Jonathan Duchenne

Role: primary

0471468241

Lise Laclautre

Role: primary

+33473754963

Damien Viglino

Role: primary

0476766784

Alizée Gagnaire

Role: primary

0471043104

Karim Tazarourte

Role: primary

0472110041

Dora Furnon

Role: primary

Sébastien Loiseau

Role: primary

0470027210

Fabien Thomas

Role: primary

Julie Contenti

Role: primary

Vincent Garrouste

Role: primary

Yonathan Freund

Role: primary

Alain Viallon

Role: primary

0477829406

Frédéric Balen

Role: primary

Thomas Moumneh

Role: primary

0247478109

Rémi Juarez

Role: primary

Other Identifiers

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2021-A01684-37

Identifier Type: OTHER

Identifier Source: secondary_id

PHRC IR 2019 BANET

Identifier Type: -

Identifier Source: org_study_id

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