Evaluation of Antithrombin Deficiency in Patients of Intensive Care Unit Placed on Extracorporeal Membrane Oxygenation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-05

Study Completion Date

2021-05-18

Brief Summary

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Prospective, monocentric, non-interventional study in patients placed on extracorporeal membrane oxygenation (ECMO)

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Detailed Description

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Our hypothesis is that ECMO initiation is responsible for a severe decrease of antithrombin level in a high proportion of patients who develop heparin resistance.

Conditions

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Severe Cardiac Insufficiency

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Extracorporeal membrane oxygenation

Blood sample

Intervention Type BIOLOGICAL

Blood sample collection from a peripheral catheter at ECMO initiation (H0), then 2h, 6h, 12h, 24h and daily from day 2 to day 7 or at ECMO discontinuation

Interventions

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Blood sample

Blood sample collection from a peripheral catheter at ECMO initiation (H0), then 2h, 6h, 12h, 24h and daily from day 2 to day 7 or at ECMO discontinuation

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Any ICU patient of receiving veno-arterial extracorporeal membrane oxygenation
* Patients who have not expressed opposition to participate

Exclusion Criteria

* Arterial thrombosis or progressive venous thrombosis
* Contraindication to heparin
* Constitutional deficiency in antithrombin
* Patient refusal
* Minor patient
* Protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No