Posterior Circulation ASTRAL Prognostic Score

NCT ID: NCT05906420

Last Updated: 2025-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-01-01

Study Completion Date

2025-11-24

Brief Summary

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The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event \<3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Detailed Description

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Conditions

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Stroke Ischemic Stroke Acute Posterior Circulation Brain Infarction Risk Score

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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ASTRAL

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Basel cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Berlin cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Bern Cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Bologna cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Dijon cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Lisbon cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Israel cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Innsbruck cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

St. Gallen cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Lugano cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Chicago cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

West Virginia cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Zurich cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Seoul cohort

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

ASTRAL prognostic score

Interventions

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ASTRAL prognostic score

ASTRAL prognostic score

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Isolated posterior circulation strokes based on clinical or/and imaging evidence.
* Arriving within 24h at hospital since last proof of good health.

Exclusion Criteria

* no available data for 3 months modified Rankin Score
* modified Rankin Score≄3 prior the event
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Lausanne

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire Vaudois

OTHER

Sponsor Role collaborator

University of Thessaly

OTHER

Sponsor Role lead

Responsible Party

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George Ntaios

Professor of Internal Medicine George Ntaios

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki

Thessaloniki, Central Macedonia, Greece

Site Status

Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne

Lausanne, Vaud Canton, Switzerland

Site Status

Countries

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Greece Switzerland

Other Identifiers

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pc-ASTRAL

Identifier Type: -

Identifier Source: org_study_id

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