Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score

NCT ID: NCT07122934

Last Updated: 2025-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1828 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-02-01

Study Completion Date

2025-08-08

Brief Summary

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Posterior circulation strokes (PCS) represent \~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

Detailed Description

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Conditions

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Acute Ischemic Stroke Posterior Circulation Brain Infarction Arterial Occlusion Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Development and Internal validation cohort

Assessment of cervico-cerebral arterial occlusion pattern

Intervention Type DIAGNOSTIC_TEST

Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

External validation cohort

Assessment of cervico-cerebral arterial occlusion pattern

Intervention Type DIAGNOSTIC_TEST

Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

Interventions

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Assessment of cervico-cerebral arterial occlusion pattern

Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* age \>18 years old
* admitted within 24h from last known well
* symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.

Exclusion Criteria

* simultaneous clinical and/or radiological strokes in the posterior and anterior circulation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role collaborator

Hospital de Egas Moniz

OTHER

Sponsor Role collaborator

University Hospital Heidelberg

OTHER

Sponsor Role collaborator

IRCCS Istituto delle Scienze Neurologiche di Bologna

OTHER

Sponsor Role collaborator

The University of Texas Health Science Center, Houston

OTHER

Sponsor Role collaborator

Azienda Ospedaliero-Universitaria di Modena

OTHER

Sponsor Role collaborator

Hospital Vall d'Hebron

OTHER

Sponsor Role collaborator

Boston University

OTHER

Sponsor Role collaborator

Università degli Studi di Brescia

OTHER

Sponsor Role collaborator

Medical University of Graz

OTHER

Sponsor Role collaborator

Hôpital Rothschild

OTHER

Sponsor Role collaborator

Medical University of Vienna

OTHER

Sponsor Role collaborator

Hebrew University of Jerusalem

OTHER

Sponsor Role collaborator

Michigan State University

OTHER

Sponsor Role collaborator

Medical University Innsbruck

OTHER

Sponsor Role collaborator

Ludwig-Maximilians - University of Munich

OTHER

Sponsor Role collaborator

Ospedale Policlinico San Martino

OTHER

Sponsor Role collaborator

EOC Lugano CH

UNKNOWN

Sponsor Role collaborator

University Hospital, Basel, Switzerland

OTHER

Sponsor Role collaborator

Aristotle University Of Thessaloniki

OTHER

Sponsor Role collaborator

Technische Universität Dresden

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire Vaudois

OTHER

Sponsor Role lead

Responsible Party

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Dr. med. Alexander Salerno, MD-PhD

Senior registrar

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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PC-CBS

Identifier Type: -

Identifier Source: org_study_id

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