Prognostic Markers of Post-Stroke Depression (PROMoSD)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

105 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2023-03-31

Brief Summary

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Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.

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Detailed Description

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Post-stroke depression (PSD) is an important complication after a stroke. Despite significant limitations between studies of PSD risk factors, stroke severity or post-stroke disability, prior depressive episodes, and female sex are arguably the most well-known risk factors for developing PSD, although the predictive value of these factors is limited.

A hypoechogenic brainstem raphe (BR) detected by transcranial sonography (TCS) is associated with depressive symptoms in distinct diseases but is also common with approximately 25% of the non-depressed population in Europe. The primary aim of this study is to investigate the association between BR hypoechogenicity and PSD occurrence in a prospective observational study design.

Conditions

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Acute Ischemic Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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BRH+

Acute ischemic stroke patients with brainstem raphe hypoechogenicity.

Transcranial sonography.

Intervention Type DIAGNOSTIC_TEST

Transcranial sonography examination to determine the brainstem raphe echogenicity.

BRH-

Acute ischemic stroke patients without brainstem raphe hypoechogenicity.

Transcranial sonography.

Intervention Type DIAGNOSTIC_TEST

Transcranial sonography examination to determine the brainstem raphe echogenicity.

Interventions

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Transcranial sonography.

Transcranial sonography examination to determine the brainstem raphe echogenicity.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Acute ischemic stroke with the onset of symptoms within the past 14 days
* Diagnosis of AIS is confirmed by brain imaging, either computer tomography or magnetic resonance imaging