Clinical Biological and Pharmacological Factors Influencing Stroke Outcome

NCT ID: NCT00763217

Last Updated: 2015-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

550 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-06-30

Study Completion Date

2012-06-30

Brief Summary

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In a previous suty, we have demonstrated that prior transient ischemic attack, treatment lipid-lowering drug or physical activity are associated to a better outcome of stroke. The aim of the study is to understand the mechanisms of this preventive neuroprotection by establishing link between biomarkers and preventive and neuroprotective measures.To answer to the question, we conduct a cohort study of stroke patients.

Detailed Description

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In the cohort, the severity of stroke (NIHSS) will be correlated with :

* clinical factors,
* pharmacological factors,
* biological factors (inflammatory markers, hemostasis...)

Conditions

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Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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stroke patient cohort

Patients with an hemispheric ischemic or hemorrhage stroke hospitalized during the 48h following the beginning of stroke

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* ischemic or hemorrhage stroke
* hemispheric stroke
* stroke dating from less 48h

Exclusion Criteria

* non hemispheric stroke
* malformative intracranial hemorrhage
* traumatic intracranial hemorrhage
* subarachnoidal hemorrhage
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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regis BORDET, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Lille University Hospital

Locations

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Lille University Hospital - Service de Neurologie vasculaire

Lille, , France

Site Status

Countries

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France

References

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Colin O, Labreuche J, Deguil J, Mendyk AM, Deken V, Cordonnier C, Deplanque D, Leys D, Bordet R. Preadmission use of benzodiazepines and stroke outcomes: the Biostroke prospective cohort study. BMJ Open. 2019 Jan 15;9(1):e022720. doi: 10.1136/bmjopen-2018-022720.

Reference Type DERIVED
PMID: 30782684 (View on PubMed)

Moulin S, Leys D, Schraen-Maschke S, Bombois S, Mendyk AM, Muhr-Tailleux A, Cordonnier C, Buee L, Pasquier F, Bordet R. Abeta1-40 and Abeta1-42 Plasmatic Levels In Stroke: Influence of Pre-Existing Cognitive Status and Stroke Characteristics. Curr Alzheimer Res. 2017;14(6):686-694. doi: 10.2174/1567205012666151027141730.

Reference Type DERIVED
PMID: 26502812 (View on PubMed)

Other Identifiers

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PHRC 2004/1901

Identifier Type: OTHER

Identifier Source: secondary_id

CP 05/15

Identifier Type: -

Identifier Source: org_study_id

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