Survival and Reproductive Outcomes of Malignant Ovarian Germ Cell Tumors
NCT ID: NCT05905289
Last Updated: 2024-02-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
27 participants
OBSERVATIONAL
2023-05-01
2023-12-11
Brief Summary
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Detailed Description
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Diagnosis of MOGCT was revealed by pelvic mass, abdominal pain, and elevated tumor markers like α-fetoprotein (AFP), human choionic gonadotophin (HCG) and lactate dehydrogenase (LDH) and confirmed by surgical procedure and pathological diagnosis. Pathological diagnosis was confirmed according to the 2014 World Health Organization classification of tumors of female reproductive organs. Tumors were staged according to American Joint Committee of Cancer (AJCC), TNM and FIGO staging system for Ovarian and Primary Peritoneal Cancer.
Fertility sparing surgery preserves uterus and the contralateral ovary with or without comprehensive staging (omentectomy and lymphadenectomy) by open laparotomy. Adjuvant chemotherapy was scheduled based on histopathology, grade and stage. All patients received chemotherapy, but with different schemes and courses The data including: subjects' demographics, clinical and pathological characteristics, treatment received, survival outcome and reproductive outcomes including pregnancy rate ( natural conception ) and live birth rate will be investigated. Follow-up data until January 31, 2022 will be collected from hospital records and telephone interview.
Conditions
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Study Design
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OTHER
RETROSPECTIVE
Study Groups
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group A
young female patients diagnosed with malignant ovarian germ cell tumors underwent fertility-sparing surgery and adjuvant chemotherapy will be retrospectively investigated
observational study
no intervention as it is an observational study
Interventions
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observational study
no intervention as it is an observational study
Eligibility Criteria
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Inclusion Criteria
* Fertility-sparing surgery and adjuvant chemotherapy.
* Pathological diagnosis of malignant ovarian germ cell tumor.
Exclusion Criteria
* Concurrent malignancy.
* Severe comorbidities that may affect ovarian reproductive function.
18 Years
35 Years
FEMALE
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Mahmoud Ahmed Ismail Abd El Hameed
Principal Investigator
Principal Investigators
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Mahmoud Ahmed Abd El Hameed, MD
Role: PRINCIPAL_INVESTIGATOR
Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University
Locations
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Department of Obstetrics & Gynecology
Cairo, , Egypt
Countries
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Other Identifiers
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N-181-2023
Identifier Type: -
Identifier Source: org_study_id
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