Clinical Outcomes of Surgery After Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer

NCT ID: NCT05888129

Last Updated: 2023-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2022-12-31

Brief Summary

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The purpose of this study was to investigate the clinical outcomes of patients with locally advanced pancreatic cancer (LA-PC) who underwent surgery after neoadjuvant chemotherapy (NACT) at Asan Medical Center's Department of Hepato-Biliary-Pancreatic Surgery from 2017 to 2020.

Detailed Description

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Pancreatic cancer (PC) has a very low survival rate. Most PC patients have non-specific symptoms that are advanced enough to be contraindications for surgical treatment; therefore, surgery is often impossible by the time PC is diagnosed. According to the NCCN guidelines, PCs with no metastases can be divided into resectable, borderline resectable , and locally advanced cases. Patients with borderline resectable PC (BR-PC) and locally advanced PC (LA-PC) currently receive multimodal therapy before surgery. The goal of these neoadjuvant treatments, including chemotherapy and radiation therapy, is to ultimately reduce local recurrence after surgery in patients with BR-PC and further improve their survival time. Additionally, several recent studies have reported results on the prognosis when surgery is performed after neoadjuvant chemotherapy (NACT) in patients with LA-PC. In the patients with LA-PC, surgery technically difficult because of major vascular invasion before NACT. Therefore, this study investigated the clinical outcomes of patients with LA-PC who underwent surgery after NACT. Additionally, the investigators evaluated factors affecting the prognosis related to survival after surgery in patients with LA-PC.

Conditions

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Postoperative Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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locally advanced pancreatic cancer

Locally advanced pancreatic cancer (LA-PC) is classified according to the National Comprehansive Cancer Networks (NCCN) guidelines.

Patients with the above conditions underwent surgery after neoadjuvant chemotherapy.

surgery after neoadjuvant chemotherapy

Intervention Type PROCEDURE

surgery after neoadjuvant chemotherapy

borderline resectable pancreatic cancer

Borderline resectable pancreatic cancer (BR-PC) is classified according to the NCCN guidelines.

Patients with the above conditions underwent surgery after neoadjuvant chemotherapy.

surgery after neoadjuvant chemotherapy

Intervention Type PROCEDURE

surgery after neoadjuvant chemotherapy

resectable pancreatic cancer

Resectable pancreatic cancer (PC) is classified according to the NCCN guidelines.

There are no arterial and venous contact with tumor Patients with the above conditions underwent upfront surgery

No interventions assigned to this group

Interventions

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surgery after neoadjuvant chemotherapy

surgery after neoadjuvant chemotherapy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* The study population consists of patients who underwent pancreatectomy for pancreatic adenocarcinoma between January 2017 and December 2020

Exclusion Criteria

* None
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Song Cheol Kim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Song Cheol Kim, MD. PhD

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

Locations

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Asan medical center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2016-0902

Identifier Type: -

Identifier Source: org_study_id

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