Multimodal Therapy Impact on Pancreatic Cancer Survival

NCT ID: NCT06938906

Last Updated: 2025-04-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

405 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-03

Study Completion Date

2025-04-30

Brief Summary

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The goal of this retrospective cohort study is to analyze change of treatment strategies affect the survival outcomes in patients of pancreatic cancer who received curative-intent treatment. The main question it aims to answer is:

Hypothesis: Change of treatment strategies involving increased utility of neoadjuvant chemotherapy and aggressive surgical approaches of extended pancreatectomy improved the overall and progression free survival in the patients with pancreatic cancer.

Participants received curative treatment for pancreatic cancer.

Detailed Description

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This study is to analyze the change of treatment strategies and shift of the paradigm over time in a single center. Researchers plan to see the impact of the evolvement to the survival outcomes in pancreatic cancer.

Conditions

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Pancreatic Cancer Neoadjuvant Chemotherapy Pancreatectomy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group A

The patient of pancreatic cancer, who began to have treatment in the period between 2011 to 2017.

No interventions assigned to this group

Group B

The patient of pancreatic cancer, who began to have treatment in the period between 2018 to 2022.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Pancreatic adenocarcinoma
* Received curative surgery

Exclusion Criteria

* Other subtypes of pancreatic cancer including acinar cell carcinoma, mucinous carcinoma, undifferentiated carcinoma and intraductal papillary mucinous neoplasm with associated adenocarcinoma
* Cases with palliative or R2 resection were also excluded from the analysis.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cheng Kung University

OTHER

Sponsor Role lead

Responsible Party

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Ting-Kai Liao

Principal Investigator, Director of Specialized Ward for Division of General Surgery, Department of Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yan-Shen Shan, MD., PhD.

Role: STUDY_CHAIR

Department of Surgery, National Cheng Kung University Hospital

Ting-Kai Liao, MD.

Role: STUDY_DIRECTOR

National Cheng-Kung University Hospital

Locations

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National Cheng Kung University Hospital

Tainan City, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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NCKUH-11405009

Identifier Type: -

Identifier Source: org_study_id

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