An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer

NCT ID: NCT06129812

Last Updated: 2023-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1132 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2021-12-31

Brief Summary

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An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer

Detailed Description

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The 1,132 patients with resectable or borderline resectable PDAC who underwent surgery between 2007 and 2021 were retrospectively reviewed. Patients with resectable PDAC without contact of major vessels (R-no contact) (n=651), with contact of portal vein or superior mesenteric vein (PV/SMV) ≤180° (R-contact) (n=306), and borderline resectable PDAC without arterial involvement (BR-V) (n=175) were analyzed.

Conditions

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Pancreatic Cancer Neoadjuvant

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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resectable PDAC with no contact to major vessels (R-no contact)

Neoadjuvant treatment

Intervention Type DRUG

Intravenous gemcitabine-based combination regimens or FOLFIRINOX were included in NAC.

resectable PDAC with contact PV/SMV of ≤180° (R-contact)

Neoadjuvant treatment

Intervention Type DRUG

Intravenous gemcitabine-based combination regimens or FOLFIRINOX were included in NAC.

borderline resectable PDAC with PV/SMV contact >180° and without arterial involvement (BR-V)

Neoadjuvant treatment

Intervention Type DRUG

Intravenous gemcitabine-based combination regimens or FOLFIRINOX were included in NAC.

Interventions

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Neoadjuvant treatment

Intravenous gemcitabine-based combination regimens or FOLFIRINOX were included in NAC.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC)
* Between January 2007 and June 2021 at Seoul National University Hospital

Exclusion Criteria

* Patients who had borderline resectable PDAC with arterial invasion
* Patients who received chemotherapy as initial treatment and did not undergo surgery
* Incomplete follow-up data for analysis
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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NAT in resectable PDAC

Identifier Type: -

Identifier Source: org_study_id

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