Reliability (Test-retest) of 30 Seconds Sit-to-stand and Timed Up and Go in Adults With Long Covid

NCT ID: NCT05886842

Last Updated: 2025-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

19 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-12-21

Study Completion Date

2024-12-21

Brief Summary

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The goal of this study is to test the reliability (with a test-retest process) of 30 seconds Sit to Stand and Timed Up and Go in an adult population with long-covid, hospitalised in a rehabilitation center.

Detailed Description

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Since December 2019, Covid-19 has affected millions of people worldwide, leaving many of them with symptoms such as fatigue, (muscle) weakness and dyspnoea, even months after their infection (long covid). Rehabilitation centers were established to aid this new group of patients. This study's aim is to test the reliability of 2 outcome measures for patients with long covid. 30 seconds Sit-To-Stand and Timed Up And Go tests are not specific to a disease but they evaluate functionality, mobility and endurance. They are easy to perform in a clinical setting as they do not require specific equipment. The reliability of the above tests has yet to be established in people with long covid.

A sample size of 19 people will be used. A difference in reliability of 0.9 and 0.7 at 80% power and a 5% level of significance using two ratings was set. Based on two testing sessions, an x value of 0.05, and a power of 0.80, a minimal sample size of 19 patients was identified (Karagiannis et al., 2020).

19 patients with long covid from the rehabilitation center will take both tests in a single day and 3 days later they will take the tests again with no physical therapy intervention in between the measurements.

For the statistical analysis, ICC (Intra-class correlation coefficients), SEM (standard error of measurement) and Bland-Altman plot will be used. These tests evaluate test-retest reliability, through the identification of the agreement of patient's scores between the 2 measurements and they evaluate the measurement precision (Savva et al, 2014).

Conditions

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Long COVID

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Test-retest

A group of 19 patients will be tested using the 30 seconds Sit-to-stand and Timed up and go tests. Each test will be repeated 3 times and the best score will be used. There is going to be 3 days waiting period before the re-tests.

Test-retest

Intervention Type OTHER

Test-retest

Interventions

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Test-retest

Test-retest

Intervention Type OTHER

Other Intervention Names

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Reliability

Eligibility Criteria

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Inclusion Criteria

* Adults who were infected with COVID-19 virus in the last 6 months and were diagnosed with long-covid
* Patients must be willing to give written consent for participation in the study
* Negative rapid test for COVID-19

Exclusion Criteria

* People under 18 years of age
* Significant cognitive and psychiatric impairments (inability to follow simple commands or give consent)
* Refuse to give consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eden Resort Wellness Rehabilitation Center

UNKNOWN

Sponsor Role collaborator

European University Cyprus

OTHER

Sponsor Role lead

Responsible Party

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Marina Kloni

Marina Eleni Kloni, BSc, MSc, MA

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Marina E Kloni

Role: PRINCIPAL_INVESTIGATOR

European University Cyprus

Locations

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Eden resort wellness rehabilitation

Larnaca, , Cyprus

Site Status

Countries

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Cyprus

References

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Figueiredo PHS, Veloso LRS, Lima MMO, Vieira CFD, Alves FL, Lacerda ACR, Lima VP, Rodrigues VGB, Maciel EHB, Costa HS. The reliability and validity of the 30-seconds sit-to-stand test and its capacity for assessment of the functional status of hemodialysis patients. J Bodyw Mov Ther. 2021 Jul;27:157-164. doi: 10.1016/j.jbmt.2021.02.020. Epub 2021 Mar 4.

Reference Type BACKGROUND
PMID: 34391227 (View on PubMed)

Hansen H, Beyer N, Frolich A, Godtfredsen N, Bieler T. Intra- and inter-rater reproducibility of the 6-minute walk test and the 30-second sit-to-stand test in patients with severe and very severe COPD. Int J Chron Obstruct Pulmon Dis. 2018 Oct 18;13:3447-3457. doi: 10.2147/COPD.S174248. eCollection 2018.

Reference Type BACKGROUND
PMID: 30425474 (View on PubMed)

Ozcan Kahraman B, Ozsoy I, Akdeniz B, Ozpelit E, Sevinc C, Acar S, Savci S. Test-retest reliability and validity of the timed up and go test and 30-second sit to stand test in patients with pulmonary hypertension. Int J Cardiol. 2020 Apr 1;304:159-163. doi: 10.1016/j.ijcard.2020.01.028. Epub 2020 Jan 15.

Reference Type BACKGROUND
PMID: 31980271 (View on PubMed)

Steffen TM, Hacker TA, Mollinger L. Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and gait speeds. Phys Ther. 2002 Feb;82(2):128-37. doi: 10.1093/ptj/82.2.128.

Reference Type BACKGROUND
PMID: 11856064 (View on PubMed)

Donner A, Eliasziw M. Sample size requirements for reliability studies. Stat Med. 1987 Jun;6(4):441-8. doi: 10.1002/sim.4780060404.

Reference Type BACKGROUND
PMID: 3629046 (View on PubMed)

Walter SD, Eliasziw M, Donner A. Sample size and optimal designs for reliability studies. Stat Med. 1998 Jan 15;17(1):101-10. doi: 10.1002/(sici)1097-0258(19980115)17:13.0.co;2-e.

Reference Type BACKGROUND
PMID: 9463853 (View on PubMed)

Karagiannis C, Savva C, Korakakis V, Matheou I, Adamide T, Georgiou A, Xanthos T. Test-Retest Reliability of Handgrip Strength in Patients with Chronic Obstructive Pulmonary Disease. COPD. 2020 Oct;17(5):568-574. doi: 10.1080/15412555.2020.1808604. Epub 2020 Aug 19.

Reference Type BACKGROUND
PMID: 32814452 (View on PubMed)

Savva C, Giakas G, Efstathiou M, Karagiannis C. Test-retest reliability of handgrip strength measurement using a hydraulic hand dynamometer in patients with cervical radiculopathy. J Manipulative Physiol Ther. 2014 Mar-Apr;37(3):206-10. doi: 10.1016/j.jmpt.2014.02.001. Epub 2014 Mar 11.

Reference Type BACKGROUND
PMID: 24630769 (View on PubMed)

Shechtman O, Gestewitz L, Kimble C. Reliability and validity of the DynEx dynamometer. J Hand Ther. 2005 Jul-Sep;18(3):339-47. doi: 10.1197/j.jht.2005.04.002.

Reference Type BACKGROUND
PMID: 16059855 (View on PubMed)

Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307-10.

Reference Type BACKGROUND
PMID: 2868172 (View on PubMed)

Myles PS, Cui J. Using the Bland-Altman method to measure agreement with repeated measures. Br J Anaesth. 2007 Sep;99(3):309-11. doi: 10.1093/bja/aem214. No abstract available.

Reference Type BACKGROUND
PMID: 17702826 (View on PubMed)

Shrout PE. Measurement reliability and agreement in psychiatry. Stat Methods Med Res. 1998 Sep;7(3):301-17. doi: 10.1177/096228029800700306.

Reference Type BACKGROUND
PMID: 9803527 (View on PubMed)

Other Identifiers

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Test-Retest

Identifier Type: -

Identifier Source: org_study_id

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