"Efficacy of Intermittent Enteral Nutrition Versus Continuous Administration in Intensive Care"
NCT ID: NCT05879263
Last Updated: 2023-05-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
190 participants
INTERVENTIONAL
2022-02-10
2024-04-30
Brief Summary
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The main question\[s\] it aims to answer are:
* Reduction of gastrointestinal and respiratory complications
* Evaluate the achievement of the caloric objective Informed consent will be requested from participants who meet the inclusion criteria.
The participants will be randomized into two groups: control group (continuous enteral nutrition) or experimental group (intermittent enteral nutrition) Researchers will compare intermittent enteral nutrition vs continuous to see if there is a reduction in gastrointestinal and respiratory complications.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
There is an allocation concealment using sealed opaque envelopes Duration: From February 2022 to complete sample number.
SUPPORTIVE_CARE
NONE
Study Groups
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INTERMITTENT ENTERAL NUTRITITION (IEN)
Administration of Enteral Nutriton (EN) by nasogastric tube in 4 bolus (24h): Duration of the infusion 1hour each shot, using an infusion pump.
INTERMITTENT ENTERAL NUTRITITION (IEN)
Administration of Enteral Nutriton (EN) by nasogastric tube in 4 bolus (24h): Duration of the infusion 1hour each shot, using an infusion pump.
CONTINUOUS ENTERAL NUTRITION (CEN)
Administration of Enteral Nutriton (EN) by nasogastric tube during 24 hours, using an infusion pump.
CONTINUOS ENTERAL NUTRITITION (CEN)
Administration of Enteral Nutriton (EN) by nasogastric tube during 24 hours, using an infusion pump.
Interventions
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INTERMITTENT ENTERAL NUTRITITION (IEN)
Administration of Enteral Nutriton (EN) by nasogastric tube in 4 bolus (24h): Duration of the infusion 1hour each shot, using an infusion pump.
CONTINUOS ENTERAL NUTRITITION (CEN)
Administration of Enteral Nutriton (EN) by nasogastric tube during 24 hours, using an infusion pump.
Eligibility Criteria
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Inclusion Criteria
* Need for enteral nutrition by nasogastric tube in the first 48 hours
* Signed informed consent
Exclusion Criteria
* Abdominal surgery
* Dire prognosis
18 Years
ALL
No
Sponsors
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University of Castilla-La Mancha
OTHER
Complejo Hospitalario Universitario de Albacete
OTHER
Responsible Party
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Maria Dolores Saiz Vinuesa
Principal Investigator
Principal Investigators
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M.Dolores Saiz-Vinuesa, NURSE
Role: PRINCIPAL_INVESTIGATOR
Gerencia de Atención Integrada de Albacete
Locations
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Maria Dolores Saiz Vinuesa
Albacete, , Spain
Countries
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Central Contacts
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Facility Contacts
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References
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Chen YC. Critical analysis of the factors associated with enteral feeding in preventing VAP: a systematic review. J Chin Med Assoc. 2009 Apr;72(4):171-8. doi: 10.1016/S1726-4901(09)70049-8.
Lewis SR, Schofield-Robinson OJ, Alderson P, Smith AF. Enteral versus parenteral nutrition and enteral versus a combination of enteral and parenteral nutrition for adults in the intensive care unit. Cochrane Database Syst Rev. 2018 Jun 8;6(6):CD012276. doi: 10.1002/14651858.CD012276.pub2.
Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, Hiesmayr M, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Oczkowski S, Szczeklik W, Bischoff SC. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019 Feb;38(1):48-79. doi: 10.1016/j.clnu.2018.08.037. Epub 2018 Sep 29.
Patel JJ, Rosenthal MD, Heyland DK. Intermittent versus continuous feeding in critically ill adults. Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):116-120. doi: 10.1097/MCO.0000000000000447.
Tavares de Araujo VM, Gomes PC, Caporossi C. Enteral nutrition in critical patients; should the administration be continuous or intermittent? Nutr Hosp. 2014 Mar 1;29(3):563-7. doi: 10.3305/nh.2014.29.3.7169.
Serpa LF, Kimura M, Faintuch J, Ceconello I. Effects of continuous versus bolus infusion of enteral nutrition in critical patients. Rev Hosp Clin Fac Med Sao Paulo. 2003 Jan-Feb;58(1):9-14. doi: 10.1590/s0041-87812003000100003. Epub 2003 Apr 30.
Ichimaru S. Methods of Enteral Nutrition Administration in Critically Ill Patients: Continuous, Cyclic, Intermittent, and Bolus Feeding. Nutr Clin Pract. 2018 Dec;33(6):790-795. doi: 10.1002/ncp.10105. Epub 2018 Jun 20.
Thong D, Halim Z, Chia J, Chua F, Wong A. Systematic review and meta-analysis of the effectiveness of continuous vs intermittent enteral nutrition in critically ill adults. JPEN J Parenter Enteral Nutr. 2022 Aug;46(6):1243-1257. doi: 10.1002/jpen.2324. Epub 2022 Feb 13.
Heffernan AJ, Talekar C, Henain M, Purcell L, Palmer M, White H. Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis. Crit Care. 2022 Oct 25;26(1):325. doi: 10.1186/s13054-022-04140-8.
Related Links
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Effectiveness of continuous enteral nutrition versus intermittent enteral nutrition in intensive care patients: a systematic review.
Other Identifiers
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CHUA_59_07_2021
Identifier Type: -
Identifier Source: org_study_id
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