Optimal Feeding Tube Dwell Time in VLBW Infants to Reduce Feeding Tube Contamination

NCT ID: NCT03728608

Last Updated: 2025-02-03

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

151 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-10

Study Completion Date

2023-05-31

Brief Summary

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The study team will determine whether a decreased feeding tube dwell time will reduce feeding tube contamination

Detailed Description

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Contaminated feeding tubes can occur in the neonatal intensive care unit (NICU) and have been associated with significant morbidity. Due to an immature immunologic systems, premature infants are at significant risk of complications related to contaminated feeding tubes. Feeding tube dwell time may affect the level of contamination. This study will determine if a maximum feeding tube dwell time of 48 hours reduces contamination compared to a maximum feeding tube dwell time of 7 days, thereby improving neonatal health outcomes.

Conditions

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Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Group 1--Short Dwell

Premature VLBW (very low birth weight) male and female infants will be randomly assigned to have their feeding tubes removed at 0-48 hours for the first 4 weeks of life.The feeding tube lumen, interluminal liquid and hub will be analyzed for level of contamination.

Group Type ACTIVE_COMPARATOR

Feeding tube dwell time of 48 hours

Intervention Type DEVICE

Feeding tube dwell time of 48 hours for first 4 weeks of life.

Group 2--Long Dwell

Premature VLBW (very low birth weight) male and female infants will be randomly assigned to have their feeding tubes removed at 7 days for the first 4 weeks of life.The feeding tube lumen, interluminal liquid and hub will be analyzed for level of contamination.

Group Type ACTIVE_COMPARATOR

Feeding tube dwell time of 7 day

Intervention Type DEVICE

Feeding tube dwell time of 7 days for first 4 weeks of life.

Interventions

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Feeding tube dwell time of 48 hours

Feeding tube dwell time of 48 hours for first 4 weeks of life.

Intervention Type DEVICE

Feeding tube dwell time of 7 day

Feeding tube dwell time of 7 days for first 4 weeks of life.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* be born to a mother who is at least 18 years of age and English or Spanish speaking
* born at \< or equal to 30 weeks
* have a birthweight \< or equal to 1500 grams
* be born to a mother who is COVID Negative
* have a feeding tube placed within 24 hours of birth
* be expected to require a feeding tube for 4 weeks following birth.

Exclusion Criteria

* infant with known congenital GI anomalies
* infants which are not expected to live
* infants will be withdrawn from the study if they require abdominal surgery for GI morbidities
Minimum Eligible Age

30 Weeks

Maximum Eligible Age

40 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Nursing Research (NINR)

NIH

Sponsor Role collaborator

National Center for Advancing Translational Sciences (NCATS)

NIH

Sponsor Role collaborator

University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Leslie Parker

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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Unversity of Florida

Gainesville, Florida, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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R01NR016964-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

5KL2TR001429

Identifier Type: NIH

Identifier Source: secondary_id

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5R01NR016964-04

Identifier Type: NIH

Identifier Source: secondary_id

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IRB201700398 -N-A

Identifier Type: -

Identifier Source: org_study_id

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