Barotrauma in Adults With Critical COVID-19

NCT ID: NCT05877443

Last Updated: 2023-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

669 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-01

Study Completion Date

2021-08-29

Brief Summary

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During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19. If this is complications of the respiratory support used to treat patients hypoxemia or if it is a direct consequence of COVID-19 damaging the lung tissue is not known.

The aim of this study is to investigate the incidence and type barotrauma, if there is an association between barotrauma and level of respiratory support used in the intensive care unit, and if barotrauma is associated with worse outcome compared to patients without barotrauma.

Detailed Description

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Conditions

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COVID-19 Barotrauma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Respiratory support by an open system

Open system

Intervention Type PROCEDURE

Oxygen delivered on open system, for example high flow nasal cannula or low flow oxygen by nasal cannula or face mask

Respiratory support by non-invasive mechanical ventilation

Non-invasive mechanical ventilation

Intervention Type PROCEDURE

Respiratory support by for example continues or bilevel positive airway pressure

Respiratory support by invasive mechanical ventilation

Invasive mechanical ventilation

Intervention Type PROCEDURE

Respiratory support delivered through endotracheal tube or tracheostomy

Interventions

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Open system

Oxygen delivered on open system, for example high flow nasal cannula or low flow oxygen by nasal cannula or face mask

Intervention Type PROCEDURE

Non-invasive mechanical ventilation

Respiratory support by for example continues or bilevel positive airway pressure

Intervention Type PROCEDURE

Invasive mechanical ventilation

Respiratory support delivered through endotracheal tube or tracheostomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Positive polymerase chain reaction for SARS-CoV-2
* Admitted to ICU due to respiratory failure

Exclusion Criteria

* Transferred to or from an ICU in other hospital/region making data collection regarding baseline data/outcomes not possible
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Sandra Jonmarker

Consultant in intensive care and anaesthesia, Ph D

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sandra Jonmarker, Ph D

Role: PRINCIPAL_INVESTIGATOR

Stockholm South General Hospital

Locations

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Södersjukhuset

Stockholm, , Sweden

Site Status

Countries

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Sweden

References

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Jensen AL, Litorell J, Grip J, Dahlberg M, Joelsson-Alm E, Jonmarker S. A descriptive, retrospective single-centre study of air-leak syndrome in intensive care unit patients with COVID-19. Acta Anaesthesiol Scand. 2025 Mar;69(3):e14582. doi: 10.1111/aas.14582.

Reference Type DERIVED
PMID: 39936659 (View on PubMed)

Other Identifiers

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Barotrauma COVID-19

Identifier Type: -

Identifier Source: org_study_id

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