Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)

NCT ID: NCT05841589

Last Updated: 2023-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-21

Study Completion Date

2021-12-01

Brief Summary

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the aim of the clinical trial is to evaluate the antimicrobial efficacy of the herbal mouth rinses against chlorhexidine mouth rinse.

Detailed Description

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The present study was carried out on 84 children. Children were recruited based on certain inclusion criteria after signing a written informed consent by their parents. They were divided into 4 groups. Group (I) the children rinsed with Chlorhexidine mouth rinse, the child rinsed for 1 minute and plaque samples were collected from the child before and after rinsing. Group (II) children rinsed with green tea extract, while group (III) children rinsed with garlic with lime extract and group (IV) the children rinsed with pomegranate extract mouth rinse with the same procedures. .child satisfaction was measured using 5-point pictorial likert scale which is graded from 1 to 5 (1.Excellent.2.Good.3 Average 4.Poor. 5. Very poor).

All the plaque samples were collected and put in sterile test tubes containing thioglycolate as a transport media. They transferred to the microbiology laboratory within half an hour after rinsing for detection of bacterial counts. These samples were incubated 48-96 hours at 37°C. Number of bacterial colonies were counted by hand-held digital colony counter.

Conditions

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Dental Caries

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

the four groups of the mouth rinses were done in parallel with each other
Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors
the participant didn't know what he rinsed with the prescribed group of mouth rinse.

the outcome assessor didn't know what group of mouth rinse belong to the bacterial count that was evaluated.

Study Groups

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Green tea extract mouth rinse

group green tea extract

Group Type EXPERIMENTAL

Green tea extract mouth rinse

Intervention Type PROCEDURE

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Garlic with lime extract mouth rinse

garlic with lime extract

Group Type EXPERIMENTAL

Garlic with lime extract mouth rinse

Intervention Type PROCEDURE

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Pomegranate extract mouth rinse

pomegranate extract

Group Type EXPERIMENTAL

Pomegranate extract mouth rinse

Intervention Type PROCEDURE

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Chlorhexidine mouth rinse

chlorhexidine

Group Type EXPERIMENTAL

Chlorhexidine mouth rinse

Intervention Type PROCEDURE

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Interventions

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Green tea extract mouth rinse

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Intervention Type PROCEDURE

Garlic with lime extract mouth rinse

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Intervention Type PROCEDURE

Pomegranate extract mouth rinse

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Intervention Type PROCEDURE

Chlorhexidine mouth rinse

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* No history of systemic disease.
* Patients didn't received antibiotics for at least 3 months before and during the study

Exclusion Criteria

* Fixed or removable orthodontic appliances.
* Children with intra oral abscess, oral lesions or gingival diseases.
* Parental consent was not acquired
Minimum Eligible Age

5 Years

Maximum Eligible Age

8 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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omnia sayed

OTHER

Sponsor Role lead

Responsible Party

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omnia sayed

Principal investigator and demonstrator at Pediatric Dentistry & Dental Public Health Department

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Ain Shmas University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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PED18-8M

Identifier Type: -

Identifier Source: org_study_id

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