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Children Acceptance of AgNP Mouthwash Against Chlorhexidine Mouthwash

NCT ID: NCT07200063

Last Updated: 2025-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2026-06-30

Brief Summary

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This study aims to evaluate and compare the children's acceptance of mouthwash containing silver nanoparticles versus Chlorhexidine.

Detailed Description

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Effective management of dental plaque is crucial for preventing periodontal diseases, dental caries, and other oral health complications. Oral hygiene can be maintained through both chemical and mechanical methods. Chemical methods are particularly beneficial in situations where mechanical cleaning proves challenging. Mouthwashes represent a significant chemical strategy for controlling plaque. Among different types of mouthwashes, chlorhexidine is considered the gold standard due to its high efficacy against a broad spectrum of bacteria and its role in plaque management, which helps prevent periodontal diseases. However, it is important to note that chlorhexidine has several side effects, such as numbness, changes in taste perception, dental staining, and an unpleasant bitter taste.

In modern applications, nanotechnology is being utilized more frequently, especially with the integration of nanoparticle materials. Silver nanoparticles, in particular, are widely used in the medical field because of their remarkable antibacterial effects on oral biofilms associated with periodontal disease.

Therefore, this research aims to evaluate the children's acceptance of chlorhexidine mouthwash in children compared to a mouthwash containing silver nanoparticles, as well as to assess their respective impacts on gingivitis.

Conditions

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Teeth Staining Numbness of the Tongue and Soft Tissue Bitter Taste

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

randomized clinical trail on three groups
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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use AgNP mouthwash as experimental group

nano cure mouthwash

Group Type EXPERIMENTAL

nano silver mouthwash

Intervention Type OTHER

nano silver mouthwash will reduce the side effect of chlorhexidine and increase acceptance of the mouthwash to patients

use hexitol mouthwash (CHX) as experimental group

Group Type EXPERIMENTAL

Chlorhexidine mouthwash (0.12%)

Intervention Type OTHER

the concentration of chlorhexidine

orovex mouthwash (CHX) as a comparator group

Group Type ACTIVE_COMPARATOR

Chlorhexidine mouthwash (0.2%)

Intervention Type OTHER

chlorhexidine mouthwash 0.2% (orovex )

Interventions

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nano silver mouthwash

nano silver mouthwash will reduce the side effect of chlorhexidine and increase acceptance of the mouthwash to patients

Intervention Type OTHER

Chlorhexidine mouthwash (0.12%)

the concentration of chlorhexidine

Intervention Type OTHER

Chlorhexidine mouthwash (0.2%)

chlorhexidine mouthwash 0.2% (orovex )

Intervention Type OTHER

Other Intervention Names

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orovex

Eligibility Criteria

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Inclusion Criteria

* Children aged from 6 to 12 in good general health and medically free
* Cooperative patient who will care about attending the follow-up visit
* Acceptance of the parents to sign the informed consent

Exclusion Criteria

* Children who are unable to attend the follow-up visit
* Medically compromised patient
* Handi-capped patient
* Parents refuse to sign informed consent
Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Ibrahem Mohamed Ibrahem Arafat

Master's student (Dentist)

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Ibrahem mohamed Arafat

Role: CONTACT

Phone: 0201004769096

Email: [email protected]

Other Identifiers

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AgNP vs CHX Mouthwashes

Identifier Type: -

Identifier Source: org_study_id