The Effect of Pomegranate Peel, German Chamomile or Their Combination on Gingivitis
NCT ID: NCT05951647
Last Updated: 2023-07-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE3
60 participants
INTERVENTIONAL
2023-07-11
2023-11-30
Brief Summary
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Detailed Description
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2. All participants should agree to take part in this clinical study and will provide informed consent.
3. Sixty plaque induced gingivitis patients ,will be recruited from Faculty of Dentistry, Alexandria University.
4. The 60 participants will be randomly assigned into 5 groups. Group 1: Patients will be managed by scaling. Group 2: Patients will be managed by scaling and will use 0.12%% chlorohexidine mouthwash in a dose of 15 ml twice daily.
Group 3: Patients will be managed by scaling and will use 5% chamomile extract mouthwash in a dose of 15 ml twice daily.
Group 4: Patients will be managed by scaling and will use 5% pomegranate peel extract mouth wash in a dose of 15 ml twice daily.
Group 5: Patients will be managed by scaling and will use a combination of 5% chamomile extract and pomegranate peel extract mouthwash in a dose of 15 ml twice daily.
5. All patients will be submitted to:
* Full patient history and clinical examination.
* Gingival index will be measured
* Saliva samples will be obtained in order to conduct ELISA for the selected biomarkers.
* Different mouthwashes will be provided to patients.
6. Statistical tests appropriate to the study design will be conducted to evaluate the significance of the results.
7. Results, conclusion, discussion and recommendations will be given.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Scaling
12 patients will be managed by scaling only
Scaling
Patients will be managed by scaling
Scaling and Chlorohexidine mouthwash
Patients will be managed by scaling and will use 0.12%% chlorohexidine mouthwash in a dose of 15 ml twice daily.
Scaling and Chlorohexidine mouthwash
scaling and will use 0.12%% chlorohexidine mouthwash in a dose of 15 ml twice daily.
Scaling and Chamomile extract mouthwash
Patients will be managed by scaling and will use 5% chamomile extract mouthwash in a dose of 15 ml twice daily.
Chamomile extract mouthwash
5% chamomile extract mouthwash in a dose of 15 ml twice daily.
Scaling and Pomegranate peel extract mouthwash
Patients will be managed by scaling and will use 5% pomegranate peel extract mouth wash in a dose of 15 ml twice daily.
Pomegranate peel extract mouth wash
5% pomegranate peel extract mouth wash in a dose of 15 ml twice daily.
Scaling and Chamomile extract mixed with Pomegranate peel extract mouthwash
Patients will be managed by scaling and will use a combination of 5% chamomile extract and pomegranate peel extract mouthwash in a dose of 15 ml twice daily.
Combination of 5% chamomile extract and pomegranate peel extract mouthwash
Use a combination of 5% chamomile extract and pomegranate peel extract mouthwash in a dose of 15 ml twice daily.
Interventions
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Chamomile extract mouthwash
5% chamomile extract mouthwash in a dose of 15 ml twice daily.
Pomegranate peel extract mouth wash
5% pomegranate peel extract mouth wash in a dose of 15 ml twice daily.
Combination of 5% chamomile extract and pomegranate peel extract mouthwash
Use a combination of 5% chamomile extract and pomegranate peel extract mouthwash in a dose of 15 ml twice daily.
Scaling
Patients will be managed by scaling
Scaling and Chlorohexidine mouthwash
scaling and will use 0.12%% chlorohexidine mouthwash in a dose of 15 ml twice daily.
Eligibility Criteria
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Inclusion Criteria
* Patients with plaque induced gingivitis.
Exclusion Criteria
* Smokers
* Pregnant females
* Patients receiving orthodontic treatment
25 Years
50 Years
ALL
No
Sponsors
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Alexandria University
OTHER
Responsible Party
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Principal Investigators
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Eman Sh Anwar, PhD
Role: PRINCIPAL_INVESTIGATOR
Faculty of Pharmacy, Alexandria University
Maha R Taalab, PhD
Role: PRINCIPAL_INVESTIGATOR
Alexandria University
Doaa A Ghareeb, PhD
Role: PRINCIPAL_INVESTIGATOR
Faculty of Science, Alexandria University
Noha A Hamdy, PhD
Role: PRINCIPAL_INVESTIGATOR
Faculty of Pharmacy, Alexandria University
Marwa A Alashwah, PharmD
Role: PRINCIPAL_INVESTIGATOR
Faculty of Pharmacy, Alexandria University
Locations
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Faculty of Pharmacy, Alexandria University
Alexandria, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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0107722
Identifier Type: -
Identifier Source: org_study_id
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