Influence of Obesity on Microvascular Reactivity During General Anesthesia
NCT ID: NCT05829785
Last Updated: 2023-10-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
128 participants
OBSERVATIONAL
2018-06-01
2021-02-28
Brief Summary
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For this prospective observation investigation, a total of 128 patients who underwent elective surgery under general anesthesia at Pusan National University Hospital between June 2018 and February 2021 were participated in this study. Baseline StO2 on thenar eminence, hemodynamics, and laboratory profile were monitored before (Tpre) and 30 min after general anesthesia (Tpost). During vascular occlusion tests (VOT), the occlusion slope representing oxygen consumption of muscle and recovery slope representing microvascular reactivity were also collected at Tpre and Tpost. For analysis, the patients were divided into two groups: overweight (body mass index \[BMI\] ≥ 25 kg/m2) and normal weight (BMI \< 25).
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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overweight group
Subjects with a body mass index (BMI) ≥ 25
Near-infrared spectroscopy monitor
tissue oxygen saturation monitoring combined with vascular occlusion test
normal weight group
Subjects with BMI \< 25
Near-infrared spectroscopy monitor
tissue oxygen saturation monitoring combined with vascular occlusion test
Interventions
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Near-infrared spectroscopy monitor
tissue oxygen saturation monitoring combined with vascular occlusion test
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* patients with a neuraxial block
* uncontrolled hypertension
* patients with major cardiovascular disease
* diabetes
* pregnant individuals
* peripheral vascular disease
* chronic venous insufficiency
* smoking: Pack-years \> 10
* chronic obstructive and restrictive pulmonary disease
18 Years
ALL
No
Sponsors
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Pusan National University Hospital
OTHER
Responsible Party
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Hyeon-Jeong Lee
Dr.
Locations
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Pusan National University Hospital
Busan, , South Korea
Countries
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References
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Cho AR, Lee HJ, Kim HJ, Do W, Jeon S, Baek SH, Kim ES, Kwon JY, Kim HK. Microvascular Reactivity Measured by Dynamic Near-infrared Spectroscopy Following Induction of General Anesthesia in Healthy Patients: Observation of Age-related Change. Int J Med Sci. 2021 Jan 1;18(5):1096-1103. doi: 10.7150/ijms.52433. eCollection 2021.
Other Identifiers
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1804-025-066
Identifier Type: OTHER
Identifier Source: secondary_id
2018-0175
Identifier Type: -
Identifier Source: org_study_id
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