Immunological Indices and Infections Among Pesticide Applicators in Sohag Governorate

NCT ID: NCT05828563

Last Updated: 2023-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-01

Study Completion Date

2024-05-01

Brief Summary

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The human body gets exposure to pesticides either directly or indirectly. By using pesticides on crops, humans come in direct contact with them and they affect the heaith

Immune system is the first defense line against pathogenic organisms; however, it is altered by the vulnerable environmental factors such as pesticides, which can cause structural or functional alterations in humoral or cell mechanisms (nonspecific or adaptive) of the immune response which lead to an increase in the susceptibility to infections

Detailed Description

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Conditions

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Pesticide Adverse Reaction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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pesticide applicators

This group contain cases

Group Type ACTIVE_COMPARATOR

Blood sample test

Intervention Type DIAGNOSTIC_TEST

Blood sample will be taken to determine immunological indices

control

control group

Group Type ACTIVE_COMPARATOR

Blood sample test

Intervention Type DIAGNOSTIC_TEST

Blood sample will be taken to determine immunological indices

Interventions

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Blood sample test

Blood sample will be taken to determine immunological indices

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. pesticide applicators
2. Age ;20-60 years
3. Exposure to pesticides for more than 3 months

Exclusion Criteria

* Subjects have recent severe trauma or surgery or recent infections
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Yara Mohamed Ahmed

DEMONSTRATOR

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sohag University

Sohag, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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yara M Ahmed, demonstrator

Role: CONTACT

01019246020

Nada A Mohamad, Professor

Role: CONTACT

01116669244

Facility Contacts

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Magdy M Amin, Professor

Role: primary

References

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Hadnagy W, Leng G, Sugiri D, Ranft U, Idel H. Pyrethroids used indoors--immune status of humans exposed to pyrethroids following a pest control operation--a one year follow-up study. Int J Hyg Environ Health. 2003 Mar;206(2):93-102. doi: 10.1078/1438-4639-00201.

Reference Type BACKGROUND
PMID: 12708230 (View on PubMed)

Kalyabina VP, Esimbekova EN, Kopylova KV, Kratasyuk VA. Pesticides: formulants, distribution pathways and effects on human health - a review. Toxicol Rep. 2021 Jun 6;8:1179-1192. doi: 10.1016/j.toxrep.2021.06.004. eCollection 2021.

Reference Type BACKGROUND
PMID: 34150527 (View on PubMed)

Zhang W, Lin Z, Pang S, Bhatt P, Chen S. Insights Into the Biodegradation of Lindane (gamma-Hexachlorocyclohexane) Using a Microbial System. Front Microbiol. 2020 Mar 27;11:522. doi: 10.3389/fmicb.2020.00522. eCollection 2020.

Reference Type BACKGROUND
PMID: 32292398 (View on PubMed)

Other Identifiers

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Soh-Med-23-4-05MS

Identifier Type: -

Identifier Source: org_study_id

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