Effect of Zinc Supplementation on Serum Zinc Level in Nursing Home Elderly

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2011-01-31

Brief Summary

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Background: Zinc supplementation has the potential to improve serum zinc levels and immunity of zinc deficient nursing home elderly.

Objective: To determine the effect of zinc supplementation of 30mg/d for 3 months on serum zinc levels and T-cell mediated function of zinc deficient nursing home elderly.

Design: This is a randomized, double-blind, placebo-controlled study. Outcome measures included change in serum zinc levels and various T-cell mediated immune factors between baseline and month 3.

Hypotheses: The investigators hypothesize that zinc supplementation of 30mg/d for 3 months will improve serum zinc levels as well as various T-cell mediated immune factors in zinc deficient nursing home elderly.

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Detailed Description

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Four hundred and forty-two medical charts were screened from three participating nursing homes; 53 nursing home elderly were eligible and therefore were screened for low serum zinc levels (\<70µg/dL). Of these, 31 (58%) had low serum zinc levels. Participants were randomized into either the placebo (N=16) or the zinc supplemented (N=15) group. Six participants did not complete the study for various reasons including refusal to take study capsules, and advice from their physicians; one participant in the zinc group experienced nausea on two consecutive days following ingestion of the zinc capsule at the beginning of the study. A total of 25 participants completed the study with 13 and 12 receiving the placebo and zinc capsules, respectively, over a period of three months

Conditions

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Disorder of Immune Function

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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30mg/day zinc supplementation

30mg/day of zinc supplement provided for 3 months to zinc deficient elderly

Group Type EXPERIMENTAL

zinc supplementation

Intervention Type OTHER

30mg/day of zinc in the form of zinc gluconate

Interventions

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zinc supplementation

30mg/day of zinc in the form of zinc gluconate

Intervention Type OTHER

Other Intervention Names

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zinc was provided in the form of zinc gluconate

Eligibility Criteria

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Inclusion Criteria

1. Males and females ≥65 years of age.
2. More than 6 months life expectancy, in the judgment of their study physician.
3. Willing to be randomized to one of the treatment groups.
4. Able to swallow pills.
5. Not currently on antibiotics.
6. Subjects consuming DRI levels of supplements and willing to replace their supplement with our control supplement.
7. Supplements of calcium, vitamin D, and iron will be permitted.
8. Willing to receive influenza vaccine.

Exclusion Criteria

1. Anticipated transfer or discharge within three months of enrollment.
2. Bed- or room-bound continuously for the last three months.
3. Presence of lung neoplastic diseases or other active neoplastic diseases requiring chemotherapy and/or use of immunosuppressive drugs (including no more than 10 mg/day of prednisone).
4. Naso-gastric or other tube feeding.
5. Long-term intravenous or urethral catheters (30 days).
6. Presence of tracheostomy or chronically ventilator-dependent.
7. Consuming supplements containing more than the DRI level of nutrients known to affect the immune response, i.e. vitamins E, C, B6, selenium, zinc, or β -carotene and unwilling to stop.

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes