Cryptosporidium Species in Sohag Governorate

NCT ID: NCT05208970

Last Updated: 2024-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-01

Study Completion Date

2025-01-31

Brief Summary

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Cryptosporidium species are increasingly recognized as important enteric pathogens that infect a broad range of hosts including human, domestic and wild animals worldwide, causing asymptomatic or mild-to-severe gastrointestinal disease in their host species.

There are 38 species of Cryptosporidium that have been described, going from amphibian parasites to mammals ones, with over 40 genotypes infecting mammals, although Cryptosporidium parvum and Cryptosporidium hominis are the two species predominantly reported in human infections. In Cairo and Sharkyia governorates in Egypt, Cryptosporidium is a common intestinal parasite among children, especially in diarrheic, preschool-aged children, with a predominance of C. hominis indicates anthroponotic rather than zoonotic transmission. Also in the sohag governorate, Cryptosporidium infection is a common intestinal parasite, as in the last five years its prevalence about 35% but there is no study clarify predominant genotype of Cryptosporidium in sohag.

Detailed Description

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Conditions

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Cryptosporidiosis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

1. Age: any age
2. Sex: male -female
3. Residence: rural-urban
4. Animal contact.
5. Immune status: immunocompetent - immunocompromised
6. Clinical manifestations: diarrhea -abdominal pain- fever- vomiting.

Exclusion Criteria

* patients taking treatment for cryptosporidiosis
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Salwa Gamal Ahmed Omran

assistant lecturer of medical parasitology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Medicine, Sohag University

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Salwa GA Omran, assistant lecturer

Role: CONTACT

01011154173 ext. +20

Facility Contacts

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Salwa GA Omran, assistant lecturer

Role: primary

01011154173 ext. +20

References

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Benamrouz S, Guyot K, Gazzola S, Mouray A, Chassat T, Delaire B, Chabe M, Gosset P, Viscogliosi E, Dei-Cas E, Creusy C, Conseil V, Certad G. Cryptosporidium parvum infection in SCID mice infected with only one oocyst: qPCR assessment of parasite replication in tissues and development of digestive cancer. PLoS One. 2012;7(12):e51232. doi: 10.1371/journal.pone.0051232. Epub 2012 Dec 13.

Reference Type BACKGROUND
PMID: 23272093 (View on PubMed)

Ryan U, Zahedi A, Paparini A. Cryptosporidium in humans and animals-a one health approach to prophylaxis. Parasite Immunol. 2016 Sep;38(9):535-47. doi: 10.1111/pim.12350.

Reference Type BACKGROUND
PMID: 27454991 (View on PubMed)

Kvac M, Havrdova N, Hlaskova L, Dankova T, Kandera J, Jezkova J, Vitovec J, Sak B, Ortega Y, Xiao L, Modry D, Chelladurai JR, Prantlova V, McEvoy J. Cryptosporidium proliferans n. sp. (Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals. PLoS One. 2016 Jan 15;11(1):e0147090. doi: 10.1371/journal.pone.0147090. eCollection 2016.

Reference Type BACKGROUND
PMID: 26771460 (View on PubMed)

Mohammad SM, Ali MS, Abdel-Rahman SA, Moustafa RA, Sarhan MH. Genotyping of Cryptosporidium species in children suffering from diarrhea in Sharkyia Governorate, Egypt. J Infect Dev Ctries. 2021 Oct 31;15(10):1539-1546. doi: 10.3855/jidc.14367.

Reference Type BACKGROUND
PMID: 34780378 (View on PubMed)

Other Identifiers

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Soh-Med-22-01-12

Identifier Type: -

Identifier Source: org_study_id

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