Treatment of Extracorporeal Membrane Oxygenation in Severe Poisoning

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-26

Study Completion Date

2025-11-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a prospective, multicentre clinical study to determine the value of the Extracorporeal Membrane Oxygenation in the treatment of critically ill poisoning patients and whether there are significant differences in the prognosis of different types or doses of poison/drug poisoning. These conclusions may guide us on how to correctly perform Extracorporeal Membrane Oxygenation, including whether or when should this treatment enabled, the mode of Extracorporeal Membrane Oxygenation, whether to combine blood purification, treatment schedule and disembarkation time.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Cross-sectional Survey of Zhejiang ECMO Application

NCT04979325

Extracorporeal Membrane Oxygenation Cardiopulmonary Resuscitation Epidemiology

UNKNOWN

Analysis of Endotoxin Activity in Patients With ECMO

NCT03978728

Cardiovascular Shock Respiratory Failure

COMPLETED

ECMO for COVID-19 vs Influenza A H1N1 Associated ARDS

NCT05080933

ARDS COVID-19 H1N1 Influenza

COMPLETED

Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients

NCT06862700

Cardiogenic Shock Extracorporeal Membrane Oxygenation Vasopressors +3 more

RECRUITING

Hemodynamic Monitoring and Fluid Responsiveness in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) - "HemodynamECMOnitoring-VA Study"

NCT06593756

ECMO Treatment ARDS Pneumonia +3 more

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study will be conducted in the Affiliated Hospital of Nantong University, the Sixth People's Hospital of Nantong University, the Branch of Affiliated Hospital of Nantong University, the People's Hospital of Qidong City, the People's Hospital of Rudong County, the People's Hospital of Rugao City, and the People's Hospital of Hai 'an City. It is expected that 60 patients with poisoning will be included, and the blood and urine samples of 60 patients will be collected and stored in the clinical trial sample database to evaluate and record the relevant indicators of the subjects. The relevant medical records in clinical treatment were analyzed and studied. Each subject will be numbered and a separate medical record will be established.

The purpose of this prospective multicenter observational clinical study was to 1) investigate the value of Extracorporeal Membrane Oxygenation in the treatment of fatal poisoning; 2) To investigate the changes of patients' organ functions (heart, lung, liver, kidney, brain) during the Extracorporeal Membrane Oxygenation operation and the influence on the removal of toxins. In order to obtain a more powerful clinical basis to guide the rational use of the Extracorporeal Membrane Oxygenation technology in patients with fatal poisoning.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Poison;Medicinal Extracorporeal Membrane Oxygenation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group A

Due to respiratory and circulatory failure caused by acute server poisoning, patients accepting extracorporeal membrane oxygenation for treatment.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Severe intoxication resulting in cardiac arrest, refractory malignant arrhythmia, refractory shock, refractory heart failure, respiratory failure.
* Denying other available methods.
* Indications for the use of the Extracorporeal membrane oxygenation exist.

Exclusion Criteria

* Severely impaired state of consciousness prior to cardiac arrest;
* Multiple organ dysfunction;
* Uncontrolled traumatic bleeding, massive gastrointestinal bleeding, and active intracranial hemorrhage;
* Left ventricular thrombosis; Severe aortic insufficiency.

Minimum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No