Extracorporeal Membrane Oxygenation in Coronavirus Disease (COVID-19), Influenza and ARDS of Other Ethiologies

NCT ID: NCT05353725

Last Updated: 2022-05-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2022-03-01

Brief Summary

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A comparison of clinical characteristics and outcomes of patients on extracorporeal membrane oxygenation (ECMO) in COVID-19, influenza and ARDS of other ethiologies

Detailed Description

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All ARDS patients on extracorporeal membrane oxygenation (ECMO) during January 1st 2016 and January 10th 2022 in University Medical Center Ljubljana were included and their clinical characteristics and outcomes were studied according to ARDS ethiology: COVID-19, influenza and other ethiologies.

Conditions

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ARDS COVID-19 Influenza

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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COVID-19 ARDS

Patients with COVID-19 ARDS on veno-venous ECMO (vvECMO)

No interventions assigned to this group

Influenza ARDS

Patients with Influenza ARDS on vvECMO

No interventions assigned to this group

ARDS of Other Ethiologies

Patients with ARDS of Other Ethiologies on vvECMO

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patient with acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO)
* 18 years or older

Exclusion Criteria

* Patient not eligible for ECMO treatment per institutional guidelines (terminal illness, palliative care)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Centre Ljubljana

OTHER

Sponsor Role lead

Responsible Party

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Jernej Berden, MD, PhD

Deputy Head of Department of Internal Intensive Care Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Fanelli V, Giani M, Grasselli G, Mojoli F, Martucci G, Grazioli L, Alessandri F, Mongodi S, Sales G, Montrucchio G, Pizzi C, Richiardi L, Lorini L, Arcadipane A, Pesenti A, Foti G, Patroniti N, Brazzi L, Ranieri V. Extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: a multicenter retrospective cohort study. Crit Care. 2022 Feb 5;26(1):34. doi: 10.1186/s13054-022-03906-4.

Reference Type BACKGROUND
PMID: 35123562 (View on PubMed)

Chong WH, Saha BK, Medarov BI. A systematic review and meta-analysis comparing the clinical characteristics and outcomes of COVID-19 and influenza patients on ECMO. Respir Investig. 2021 Nov;59(6):748-756. doi: 10.1016/j.resinv.2021.07.006. Epub 2021 Aug 17.

Reference Type BACKGROUND
PMID: 34481816 (View on PubMed)

Blazoski CM, Baram M, Yang Q, Hirose H. Outcomes of extracorporeal membrane oxygenation in influenza versus COVID-19 during the first wave of COVID-19. J Card Surg. 2021 Oct;36(10):3740-3746. doi: 10.1111/jocs.15888. Epub 2021 Aug 9.

Reference Type BACKGROUND
PMID: 34369601 (View on PubMed)

Other Identifiers

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ECMO in ARDS

Identifier Type: -

Identifier Source: org_study_id

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