Portal Hypertension Using Magnetic Resonance Elastography

NCT ID: NCT05749198

Last Updated: 2023-03-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

47 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-02

Study Completion Date

2023-01-28

Brief Summary

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This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).

Detailed Description

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Conditions

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Portal Hypertension Magnetic Resonance Imaging

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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MRE

MRE was performed using a 3T system (Magnetom Skyra; Siemens, Erlangen, Germany) equipped with a combination of a 30-channel body and a 32-channel spine matrix coil.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* diagnosed liver cirrhosis
* requiring prophylactic treatment of esophageal varices

Exclusion Criteria

* the coexistence of hepatocellular carcinoma
* refractory ascites who regularly underwent large-volume paracentesis
* the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
* undergoing liver transplantation
* contraindication with magnetic resonance imaging
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Moon Young Kim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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CR317132

Identifier Type: -

Identifier Source: org_study_id

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