Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-01

Study Completion Date

2023-01-23

Brief Summary

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The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.

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Detailed Description

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Conditions

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Potentially Malignant Lesions Oral Lichen Planus Leukoplakia, Oral

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Oral Lichen Planus

Real-time Polymerase Chain Reaction technique

Intervention Type DIAGNOSTIC_TEST

Real-time Polymerase Chain Reaction technique

Leukoplakia

Real-time Polymerase Chain Reaction technique

Intervention Type DIAGNOSTIC_TEST

Real-time Polymerase Chain Reaction technique

Healthy control

Real-time Polymerase Chain Reaction technique

Intervention Type DIAGNOSTIC_TEST

Real-time Polymerase Chain Reaction technique

Interventions

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Real-time Polymerase Chain Reaction technique

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* participants will be divided into 3 groups:

Group I: patients suffering from oral lichen planus Group II: patients suffering from leukoplakia Group III: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions.

Exclusion Criteria

* Subjects taking any drugs inducing any changes that could affect the salivary flow.
* Pregnant females.
* Subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling.
* Patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes