Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions
NCT ID: NCT02323672
Last Updated: 2017-02-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2014-02-28
2014-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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oral premalignant patients
15 patients suffering from oral premalignant lesions as lichen planus, actinic keratosis, leukoplakia and erythroplakia.
No interventions assigned to this group
oral malignant patients
15 patients suffering from oral malignant lesions
No interventions assigned to this group
control subjects
15 individuals age, gender and periodontal status matched with oral premalignant and malignant patients and not suffering from any oral mucosal lesions or periodontal disease.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* patients with oral malignant lesions.
Exclusion Criteria
40 Years
50 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Noha Ayman Ghallab
Associate Professor of periodontology and Oral Medicine, faculty of oral and dental medicine
Principal Investigators
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Noha Ghallab, M.D.
Role: PRINCIPAL_INVESTIGATOR
Associate Professor of periodontology and Oral Medicine faulty of oral and dental medicine Cairo Unv.
References
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Skrzeczynska-Moncznik J, Stefanska A, Zabel BA, Kapinska-Mrowiecka M, Butcher EC, Cichy J. Chemerin and the recruitment of NK cells to diseased skin. Acta Biochim Pol. 2009;56(2):355-60. Epub 2009 Jun 18.
Parolini S, Santoro A, Marcenaro E, Luini W, Massardi L, Facchetti F, Communi D, Parmentier M, Majorana A, Sironi M, Tabellini G, Moretta A, Sozzani S. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood. 2007 May 1;109(9):3625-32. doi: 10.1182/blood-2006-08-038844. Epub 2007 Jan 3.
Zhou XJ, Sugerman PB, Savage NW, Walsh LJ. Matrix metalloproteinases and their inhibitors in oral lichen planus. J Cutan Pathol. 2001 Feb;28(2):72-82. doi: 10.1034/j.1600-0560.2001.280203.x.
Nanda DP, Dutta K, Ganguly KK, Hajra S, Mandal SS, Biswas J, Sinha D. MMP-9 as a potential biomarker for carcinoma of oral cavity: a study in eastern India. Neoplasma. 2014;61(6):747-57. doi: 10.4149/neo_2014_091.
Wang N, Wang QJ, Feng YY, Shang W, Cai M. Overexpression of chemerin was associated with tumor angiogenesis and poor clinical outcome in squamous cell carcinoma of the oral tongue. Clin Oral Investig. 2014 Apr;18(3):997-1004. doi: 10.1007/s00784-013-1046-8. Epub 2013 Jul 19.
Other Identifiers
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chemerin_MMP-9_Oral_cancer
Identifier Type: -
Identifier Source: org_study_id
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