Short-term Evaluation of Motor and Sensory Function in Post-COVID-19 Patients

NCT ID: NCT05721040

Last Updated: 2023-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-01

Study Completion Date

2022-09-01

Brief Summary

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SARS-COV-2 infection reframed medical knowledge in many aspects, yet there is still a lot to be discovered. our aim is to evaluate neurological impact of covid-19; if there is any.

Detailed Description

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Coronavirus disease 19 (COVID-19) can cause neuropsychiatric, psychological and psychosocial impairments. Literature regarding the sensory and motor affection of COVID-19 is still limited.

Public health emergencies as COVID-19 are likely to cause adverse neuropsychiatric impacts. Cognitive impairments after SARS-COV-2 infection were noticed, COVID-19 patients complain of poor concentration, declined memory, and insomnia, as well as anxiety and depression symptoms.

in a study; Neurological manifestations described in 36.4% of 214 patients with confirmed COVID-19. However, the symptoms described \[dizziness (not further defined), headache, and impaired consciousness\] are commonplace in many severe infections and represent disturbances in neurological function rather than a neurological disease per se. Anosmia and ageusia have received much attention, but are ubiquitous in other common upper respiratory tract infections. While a reported increased risk of cerebrovascular disease.

Conditions

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Motor Neuropathy Sensory Neuropathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Covid-19 Group

Motor nerve study was performed in the median and posterior tibial nerve to assess the motor function of the upper and lower limbs.

Sensory nerve study was done for the median and sural nerves to estimate the peripheral neurological function of both upper and lower limbs.

F wave study was performed for the upper limb in the median nerve.

No interventions assigned to this group

Control Group

Motor nerve study was performed in the median and posterior tibial nerve to assess the motor function of the upper and lower limbs.

Sensory nerve study was done for the median and sural nerves to estimate the peripheral neurological function of both upper and lower limbs.

F wave study was performed for the upper limb in the median nerve.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with confirmed RT-PCR COVID-19 infection with mild to moderate severity based on the Egyptian ministry of health (MOH) protocol (version 1.4, November 2020) with neurological symptoms suggestive of peripheral neuropathy

Exclusion Criteria

* patients presenting with neurological manifestations other than peripheral neuropathy, such as stroke, cerebral hemorrhage, encephalitis, or meningitis.
* Patients with any medical condition or comorbidities that may affect the result of the study as diabetes, arthritis, and carpel tunnel syndrome.
* Severe COVID-19 patients with a critical condition that needs hospitalization and ventilatory support were also excluded from the study.
Minimum Eligible Age

20 Years

Maximum Eligible Age

68 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Waleed Gamal Elddin Khaleel

Lecturer of chest diseases and tuberculosis

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Waleed Gamal Elddin Khaleel, Lecturer

Role: PRINCIPAL_INVESTIGATOR

Assiut university, Egypt

Locations

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Assiut university hospitals

Asyut, , Egypt

Site Status

Countries

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Egypt

References

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Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127.

Reference Type BACKGROUND
PMID: 32275288 (View on PubMed)

Elshebawy H, Ezzeldin MY, Elzamarany EH. Characteristics of COVID and post COVID polyneuropathies in adults and pediatrics: an Egyptian sample. Egypt J Neurol Psychiatr Neurosurg. 2021;57(1):178. doi: 10.1186/s41983-021-00435-9. Epub 2021 Dec 20.

Reference Type BACKGROUND
PMID: 34955631 (View on PubMed)

Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T. Neurological associations of COVID-19. Lancet Neurol. 2020 Sep;19(9):767-783. doi: 10.1016/S1474-4422(20)30221-0. Epub 2020 Jul 2.

Reference Type BACKGROUND
PMID: 32622375 (View on PubMed)

Other Identifiers

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Covid-19 NCS

Identifier Type: -

Identifier Source: org_study_id

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