Green Coffee Effect on Metabolic Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-03

Study Completion Date

2022-09-30

Brief Summary

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The present study aimed to investigate the effect of green coffee bean extract (GCBE) on the inflammatory biomarkers in obese patients with a metabolic syndrome via analyzing some inflammatory biomarkers as resistin, TNF-α, total sialic acid, homocysteine, high sensitivity C-reactive protein (hs-CRP) and anti-inflammatory cytokine, adiponectin

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Detailed Description

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160 obese patients supplemented with either GCBE capsules (800 mg) daily or placebo for 6 months and advised to take a balanced diet. Blood samples were collected at baseline and after three months of supplementation

Conditions

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Supportive Care Metabolic Syndrome Obesity Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

160 obese patients supplemented with GCBE capsules (800 mg) daily for six months

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Investigators

double-blind randomised controlled study

Study Groups

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green been extract treated group

Participants included in the study were maintained on a balanced diet and supplemented with Green Coffee Bean (Coffea Arabica) extract capsules (800 mg/capsule

Group Type EXPERIMENTAL

Green coffee been extract

Intervention Type DIETARY_SUPPLEMENT

supportive treatment

Placebo group

Participants included in the study were maintained on a balanced diet and supplemented with placebo capsules.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Placebo capsule

Interventions

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Green coffee been extract

supportive treatment

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo capsule

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Participants were enrolled if they were

* aged 20-60y
* waist circumference \>102 cm in male; 88 cm in female
* triglycerides ≥150 mg/dL (1.7 mmol/L)
* HDL-C\<40 mg/dL (1.03 mmol/L) in males \& \<50 mg/dL (1.29 mmol/L) in females
* systolic BP ≥ 130 or diastolic BP ≥ 85 mm Hg.

Exclusion Criteria

* liver, kidney, coronary artery disease, type I diabetes, autoimmune diseases, cancer, infection, smoking, recent major surgery, routine coffee consumption, pregnancy or breast-feeding, use of anti-inflammatory drugs, corticosteroids, hormone replacement therapy, weight-loss and anti-hypercholesterolemic medications three months or less prior to enrolment

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No