The Effect of Intelligent Exercise on Vascular Function, Grip Strength and Adherence in Patients With AVF After Surgery
NCT ID: NCT05686200
Last Updated: 2025-12-10
Study Results
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Basic Information
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COMPLETED
NA
52 participants
INTERVENTIONAL
2023-03-08
2025-04-09
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
TRIPLE
Study Groups
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Experimental group
Participants performed wrist-forearm exercise training within 2 weeks after the operation, that is, from 24 hours to 2 weeks after the operation, twice a day in the morning and evening, 3 groups each time, and each single item was repeated 5 times in each group (maintain for 5 seconds). Exercise for 40 minutes a day, use the mobile phone to install the forearm isometric exercise software program within the 3rd to 8th week, use the Bluetooth device to connect the hand-held gripper to perform the forearm isometric exercise, 2 times a day, morning and evening, and train 3 groups each time, 20 times each time , hand grip strength for 3 seconds each time, increase by 1 second per week, and rest for 90 seconds between groups.
Forearm isometric exercise intervention program
Experimental group using the intelligent gripper for forearm isometric exercise in the 3rd to 8th participants after operation, and using the smart mobile phone to install the forearm isometric exercise training game program software to provides an interactive and real- time exercise grip strength feedback mechanism, which are uses the interest of the participant to complete the forearm isometric exercise every day, and can implement the isometric exercise training for fistulization. Study nurses will track exercise adherence with telephone interviews 2, 4 and 8 participants after participant exercise intervention.
Control group
The control group began to use soft rubber balls for isometric contraction exercise from the 2nd day to the 8th week after operation. 2 times a day in the morning and evening, 3 groups of training each time, each group holds the ball for 5 minutes, and rests for 90 seconds between groups. Each grip training must be completed 20 times within 1 minute (keep 3 seconds each time in the first week) , increase by 2 seconds every week, and keep each grasping time for 10 seconds from the 5th to the 8th week.
Forearm isometric exercise intervention program
Experimental group using the intelligent gripper for forearm isometric exercise in the 3rd to 8th participants after operation, and using the smart mobile phone to install the forearm isometric exercise training game program software to provides an interactive and real- time exercise grip strength feedback mechanism, which are uses the interest of the participant to complete the forearm isometric exercise every day, and can implement the isometric exercise training for fistulization. Study nurses will track exercise adherence with telephone interviews 2, 4 and 8 participants after participant exercise intervention.
Interventions
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Forearm isometric exercise intervention program
Experimental group using the intelligent gripper for forearm isometric exercise in the 3rd to 8th participants after operation, and using the smart mobile phone to install the forearm isometric exercise training game program software to provides an interactive and real- time exercise grip strength feedback mechanism, which are uses the interest of the participant to complete the forearm isometric exercise every day, and can implement the isometric exercise training for fistulization. Study nurses will track exercise adherence with telephone interviews 2, 4 and 8 participants after participant exercise intervention.
Eligibility Criteria
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Inclusion Criteria
* Regular follow-up in the nephrology clinic
* Diagnosed with chronic kidney disease at stage 5 (or 5D)
* Expect to do the first autologous arteriovenous fistula surgery
Exclusion Criteria
* Have undergone percutaneous transluminal angioplasty in the arm receiving autologous arteriovenous fistula
* Have undergone orthopedic disease-related surgery in the arm receiving autologous arteriovenous fistula
* Have been cardiovascular events within the past 3 months
* Have been heart function Left ventricular ejection fraction within the past 3 months \<30%.
20 Years
ALL
No
Sponsors
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Taipei Veterans General Hospital, Taiwan
OTHER_GOV
Taiwan Nurses Association
OTHER
National Taipei University of Nursing and Health Sciences
OTHER
Responsible Party
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Chia Jung Hsieh
Ph.D., RN, Associate Professor
Locations
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National Taipei University of Nursing and Health Sciences
Taipei, Taipei City, Taiwan
Countries
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References
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Alikari V, Tsironi M, Matziou V, Tzavella F, Stathoulis J, Babatsikou F, Fradelos E, Zyga S. The impact of education on knowledge, adherence and quality of life among patients on haemodialysis. Qual Life Res. 2019 Jan;28(1):73-83. doi: 10.1007/s11136-018-1989-y. Epub 2018 Sep 3.
Andrade FP, Benvenutti H, da Silva KC, Rovedder PME. Effects of upper limb exercise programs on the arteriovenous fistula in patients on hemodialysis: A systematic review and meta-analysis. J Vasc Access. 2022 Sep;23(5):770-777. doi: 10.1177/11297298211001166. Epub 2021 Apr 27.
Bohannon RW. Muscle strength: clinical and prognostic value of hand-grip dynamometry. Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):465-70. doi: 10.1097/MCO.0000000000000202.
Collado-Mateo D, Lavin-Perez AM, Penacoba C, Del Coso J, Leyton-Roman M, Luque-Casado A, Gasque P, Fernandez-Del-Olmo MA, Amado-Alonso D. Key Factors Associated with Adherence to Physical Exercise in Patients with Chronic Diseases and Older Adults: An Umbrella Review. Int J Environ Res Public Health. 2021 Feb 19;18(4):2023. doi: 10.3390/ijerph18042023.
Cronin J, Lawton T, Harris N, Kilding A, McMaster DT. A Brief Review of Handgrip Strength and Sport Performance. J Strength Cond Res. 2017 Nov;31(11):3187-3217. doi: 10.1519/JSC.0000000000002149.
Fontsere N, Mestres G, Yugueros X, Lopez T, Yuguero A, Bermudez P, Gomez F, Riambau V, Maduell F, Campistol JM. Effect of a postoperative exercise program on arteriovenous fistula maturation: A randomized controlled trial. Hemodial Int. 2016 Apr;20(2):306-14. doi: 10.1111/hdi.12376. Epub 2015 Oct 20.
Hawley-Hague H, Horne M, Skelton DA, Todd C. Review of how we should define (and measure) adherence in studies examining older adults' participation in exercise classes. BMJ Open. 2016 Jun 23;6(6):e011560. doi: 10.1136/bmjopen-2016-011560.
Ibeas J, Roca-Tey R, Vallespin J, Moreno T, Monux G, Marti-Monros A, Del Pozo JL, Gruss E, Ramirez de Arellano M, Fontsere N, Arenas MD, Merino JL, Garcia-Revillo J, Caro P, Lopez-Espada C, Gimenez-Gaibar A, Fernandez-Lucas M, Valdes P, Fernandez-Quesada F, de la Fuente N, Hernan D, Arribas P, Sanchez de la Nieta MD, Martinez MT, Barba A; por el Grupo Espanol Multidisciplinar del Acceso Vascular (GEMAV). Spanish Clinical Guidelines on Vascular Access for Haemodialysis. Nefrologia. 2017 Nov;37 Suppl 1:1-191. doi: 10.1016/j.nefro.2017.11.004. English, Spanish.
Kumar A/L S Katheraveloo K, Suryani Safri L, Guo Hou L, Hafiz Maliki A, Md Idris MA, Harunarashid H. Effect of isometric handgrip exercise on the size of cephalic veins in patients with stage 3 and 4 chronic kidney disease: A randomized controlled trial. J Vasc Access. 2020 May;21(3):372-378. doi: 10.1177/1129729819879314. Epub 2019 Oct 4.
Kong S, Lee KS, Kim J, Jang SH. The effect of two different hand exercises on grip strength, forearm circumference, and vascular maturation in patients who underwent arteriovenous fistula surgery. Ann Rehabil Med. 2014 Oct;38(5):648-57. doi: 10.5535/arm.2014.38.5.648. Epub 2014 Oct 30.
Lok CE, Huber TS, Lee T, Shenoy S, Yevzlin AS, Abreo K, Allon M, Asif A, Astor BC, Glickman MH, Graham J, Moist LM, Rajan DK, Roberts C, Vachharajani TJ, Valentini RP; National Kidney Foundation. KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update. Am J Kidney Dis. 2020 Apr;75(4 Suppl 2):S1-S164. doi: 10.1053/j.ajkd.2019.12.001. Epub 2020 Mar 12.
Nantakool S, Srisuwan T, Reanpang T, Rerkasem K, Prasannarong M. A randomized controlled trial of the effect of postoperative hand exercise training on arteriovenous fistula maturation in patients with chronic kidney disease. J Vasc Surg. 2022 Jan;75(1):230-237. doi: 10.1016/j.jvs.2021.07.124. Epub 2021 Jul 24.
Oprea A, Molnar A, Vladutiu D, Scridon T, Trifan C, Sacui D, Sasarman V, Mircea PA. Correlation between preoperative vein and artery diameters and arteriovenous fistula outcome in patients with end-stage renal disease. Clujul Med. 2018 Oct;91(4):399-407. doi: 10.15386/cjmed-1080. Epub 2018 Oct 30.
Rothuizen TC, Wong C, Quax PH, van Zonneveld AJ, Rabelink TJ, Rotmans JI. Arteriovenous access failure: more than just intimal hyperplasia? Nephrol Dial Transplant. 2013 May;28(5):1085-92. doi: 10.1093/ndt/gft068. Epub 2013 Mar 29.
Salimi F, Majd Nassiri G, Moradi M, Keshavarzian A, Farajzadegan Z, Saleki M, Nikpoor A, Ghane M. Assessment of effects of upper extremity exercise with arm tourniquet on maturity of arteriovenous fistula in hemodialysis patients. J Vasc Access. 2013 Jul-Sep;14(3):239-44. doi: 10.5301/jva.5000123. Epub 2013 Jan 3.
Schmidli J, Widmer MK, Basile C, de Donato G, Gallieni M, Gibbons CP, Haage P, Hamilton G, Hedin U, Kamper L, Lazarides MK, Lindsey B, Mestres G, Pegoraro M, Roy J, Setacci C, Shemesh D, Tordoir JHM, van Loon M, Esvs Guidelines Committee, Kolh P, de Borst GJ, Chakfe N, Debus S, Hinchliffe R, Kakkos S, Koncar I, Lindholt J, Naylor R, Vega de Ceniga M, Vermassen F, Verzini F, Esvs Guidelines Reviewers, Mohaupt M, Ricco JB, Roca-Tey R. Editor's Choice - Vascular Access: 2018 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2018 Jun;55(6):757-818. doi: 10.1016/j.ejvs.2018.02.001. Epub 2018 May 2. No abstract available.
Silva IB, Barbosa JBN, Araujo AXP, Marinho PEM. Effect of an exercise program with blood flow restriction on the muscular strength of patients with chronic kidney disease: A randomized clinical trial. J Bodyw Mov Ther. 2021 Oct;28:187-192. doi: 10.1016/j.jbmt.2021.06.022. Epub 2021 Jun 23.
Sidawy AN, Gray R, Besarab A, Henry M, Ascher E, Silva M Jr, Miller A, Scher L, Trerotola S, Gregory RT, Rutherford RB, Kent KC. Recommended standards for reports dealing with arteriovenous hemodialysis accesses. J Vasc Surg. 2002 Mar;35(3):603-10. doi: 10.1067/mva.2002.122025.
Smith GE, Gohil R, Chetter IC. Factors affecting the patency of arteriovenous fistulas for dialysis access. J Vasc Surg. 2012 Mar;55(3):849-55. doi: 10.1016/j.jvs.2011.07.095. Epub 2011 Nov 8.
Tapia Gonzalez I, Esteve Simo V, Ibanez S, Moreno Guzman F, Fulquet Nicolas M, Duarte Gallego V, Saurina Sole A, Pou Potau M, Yeste Campos M, de Arellano Serna MR. Elderly patients, isometric exercise, and native vascular access maturation: An unsolved question? Hemodial Int. 2021 Apr;25(2):154-163. doi: 10.1111/hdi.12900. Epub 2020 Nov 5.
Hart A, Lentine KL, Smith JM, Miller JM, Skeans MA, Prentice M, Robinson A, Foutz J, Booker SE, Israni AK, Hirose R, Snyder JJ. OPTN/SRTR 2019 Annual Data Report: Kidney. Am J Transplant. 2021 Feb;21 Suppl 2:21-137. doi: 10.1111/ajt.16502.
Wilschut ED, Rotmans JI, Bos EJ, van Zoest D, Eefting D, Hamming JF, van der Bogt KEA. Supervised preoperative forearm exercise to increase blood vessel diameter in patients requiring an arteriovenous access for hemodialysis: rationale and design of the PINCH trial. J Vasc Access. 2018 Jan;19(1):84-88. doi: 10.5301/jva.5000826.
Hsiao YH, Shin ML, Huang CP, Chen SJ, Huang TY. [Using Interdisciplinary Cooperation to Improve the Rate of Proper Performance of a Hand Exercise Among Hemodialysis Patients With Arteriovenous Fistula Construction]. Hu Li Za Zhi. 2017 Jun;64(3):74-81. doi: 10.6224/JN.000042. Chinese.
Chen YC, Chang P. [Using eHealth in the Continuity Care of Chronic Kidney Disease: Opportunities and Considerations]. Hu Li Za Zhi. 2016 Apr;63(2):12-8. doi: 10.6224/JN.63.2.12. Chinese.
Other Identifiers
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NTUNHS-012
Identifier Type: -
Identifier Source: org_study_id
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