Post-stroke Cognitive Impairment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

335 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-17

Study Completion Date

2026-10-31

Brief Summary

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Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.

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Detailed Description

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The study aim is to establish a model capturing patients' inter-individual variability in susceptibility to stroke damage to predict stroke-induced cognitive trajectories. This is a prospective longitudinal observational national monocentric study for 6 years (recruitment during the first 3 years). The investigators perform comprehensive neuropsychological testing in i) acute stroke phase (0-10 days post-stroke), ii) sub-acute stroke phase (3 months post-stroke), and iii) chronic stroke phase (12 months and 3 years post-stroke). At each time point, cognitive performances as well as clinical and functional status will be assessed. Furthermore, the investigators will assess the proxies of cognitive reserve and the level of post-stroke physical activity.

Conditions

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First-ever Ischemic Stroke Cognitive Performance

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Stroke patients

Adults with first-ever anterior circulation stroke

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years old
* First-ever anterior circulation ischemic stroke confirmed by routine MRI
* Time of enrollment: ≤ 10 days from stroke onset.

Exclusion Criteria

* Previous stroke anamnestic or based on clinical imaging
* Additional stroke in posterior circulation
* Conditions that preclude the cognitive testing (e.g. delirium, intubation, reduced vigilance
* Neurological or psychiatric conditions that preclude the data interpretation (e.g. pre-stroke dementia, schizophrenia, brain tumor, regular intake of benzodiazepine, depression)
* MRI contraindication
* Native language other than German, French or Italian

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No