FMRI in Monitoring Intracerebral Stem Cell Implantation for Chronic Stroke Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Brief Summary

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A growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke in animal model. But the stem cell therapy for chronic stroke patients has not been well investigated yet. In this study, the investigators will test the hypothesis that intracerebral peripheral blood hematopoietic stem cell (CD34+) (PBSC) transplantation induces neuroplasticity in chronic stroke patients. The remyelination of corticospinal tract in the lesion side, focal increased perfusion and increased cortical activity in the peri-infarcted area will be monitored by the functional MRI after stem cell therapy. The investigators study is aimed to find the potential mechanisms of the functional recovery after stem cell implantation. The investigators also hope to find image surrogate markers for prediction of patient outcome. The possible surrogate markers will be helpful in improving the treatment procedure and patient selection.

Detailed Description

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Conditions

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Stroke

Keywords

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stroke stem cell

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Old stroke half an year \~3 year
* One-sided MCA infarction
* NIHSS stroke scale: 9-20

Exclusion Criteria

* Pacemaker
* Cerebral aneurysm clips
* Neurostimulator
* Metallic heart valves
* IUD
* Joint replacement
* Metal plates
* Bone or joint pins
* Vena cava filters
* Embolization coils
* Cochlear implants
* Greenfieid filer
* Seizures
* Claustrophobia
* Bullet/gunshot
* Prosthesis (non-removeable)
* Artificial limbs (non-removeable)
* Surgical slips
* Metal screws or pins\>
* Shrapnel/metallic fragments
* Harrington rod
* Insulin pump
* Ever had metal removed from in or around the eye
* Ever been metal worker (i.e., welder, machinist)
* Non-removeable hearing aids
* Birdnest or Gianturco filter
* Pregnant

Minimum Eligible Age

35 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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China Medical University Hospital

Other Identifiers

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DMR98-IRB-031

Identifier Type: -

Identifier Source: org_study_id