Gut Microbiota and Serum Markers for Cognitive Impairment and Poor Prognosis After Ischemic Stroke
NCT ID: NCT04688138
Last Updated: 2021-08-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
600 participants
OBSERVATIONAL
2020-06-01
2023-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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ischemic stroke
Patients with ischemic stroke within 7 days of onset
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Aged between 18-75;
* Onset within 7 days;
* Sign informed consent and agree to provide relevant medical history data and biological specimens.
Exclusion Criteria
* Severe disturbance of consciousness (NIHSS consciousness score \> 1)
* Previous severe mental disorders and dementia (AD8 score ≥ 2)
* History of cerebral hemorrhage or any stroke within 12 months;
* Serious systemic diseases including malignant tumors
* Patients with aphasia and unable to cooperate to complete the Montreal Cognitive Assessment (MoCA)
* ALT or AST greater than 2 times the upper limit of normal value or severe liver disease;
* GFR less than 30mL/min/1.72m2 or severe kidney disease
* Alcohol abused, drug use and chemical poisoning history (such as pesticide poisoning)
* Patients with previous history of gastrointestinal tract or confirmed during hospitalization
* Patients who could not collect stool samples within 4 days after admission.
18 Years
75 Years
ALL
No
Sponsors
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Guangdong 999 Brain Hospital
OTHER
Zhujiang Hospital
OTHER
First Affiliated Hospital of Jinan University
OTHER
Nanfang Hospital, Southern Medical University
OTHER
Responsible Party
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Locations
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Department of Neurology, NanFang Hospital, Southern Medical University
Guanzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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References
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Ren Y, Liang J, Li X, Deng Y, Cheng S, Wu Q, Song W, He Y, Zhu J, Zhang X, Zhou H, Yin J. Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients. BMC Microbiol. 2023 Oct 24;23(1):305. doi: 10.1186/s12866-023-03057-8.
Other Identifiers
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NFEC-2020-169
Identifier Type: -
Identifier Source: org_study_id
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