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Microbe-host Interaction Relationship in Patients With Stroke-relatedPneumonia

NCT ID: NCT06161298

Last Updated: 2023-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

240 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-20

Study Completion Date

2025-06-30

Brief Summary

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This study intends to use a standardized cohort study to collect biological samples (including throat swabs, sputum and blood) from subjects eligible for inclusion, and use 16s DNA / metagenomic sequencing and metabolome technology to explore the microbial-host interaction relationship of SAP patients.

Detailed Description

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Stroke-related pneumonia (SAP) is the most common complication of acute cerebral hemorrhage, and it is one of the main causes of disease aggravation, prolonged hospitalization and costs, and even death. The traditional antibiotic model proved ineffective, and new prevention and treatment methods were urgently sought.This study intends to use a standardized and rigorous cohort study to collect biological samples (including throat swabs, sputum and blood) of eligible subjects, and to explore the microbial-host interaction relationship in patients with SAP, which may provide new targets and new ideas for the prevention and control of SAP.

Conditions

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Stroke-related Pneumonia

Keywords

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Stroke-related pneumonia micropopulation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy control group

age\> 18, without lung disease

No interventions assigned to this group

NSAP group

patients with no stroke pneumonia

No interventions assigned to this group

SAP group

Those diagnosed with stroke-related pneumonia

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age: 18 years old;
* Stroke was confirmed by imaging;
* Within 48 hours of onset, the onset time cannot be determined from the last normal observation;
* Glasgow Coma Scale (GCS) 7-14;
* SAP by clinical symptoms, laboratory examination or imaging confirmation, the modified CDC diagnostic criteria;
* The patient (or his / her legal representative) signs a written informed consent form.

Exclusion Criteria

* Use of antibiotics within 4 weeks before stroke onset;
* The presence of other conditions that may interfere with the follow-up and outcome assessment (such as known significant prestroke disability, mRS score of 3-5, end-stage malignancy, and liver and renal failure);
* Pregnant or lactating women.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Guangzhou University of Traditional Chinese Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jianwen Guo, Dr

Role: STUDY_DIRECTOR

Guangdong Province Hospital of Tradtional Chinese Medicine

Central Contacts

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Jianwen Guo, Dr

Role: CONTACT

Phone: 13724899379

Email: [email protected]

Dou Wang, Dr

Role: CONTACT

Phone: 18292998840

Email: [email protected]

Other Identifiers

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SAP20231201

Identifier Type: -

Identifier Source: org_study_id