The Relationships Between Personal Identity, Autobiographical Memory and Future Thinking in People With Multiple Sclerosis

NCT ID: NCT05648292

Last Updated: 2023-09-06

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-12-07
• Study Completion Date: 2025-06-07

Brief Summary

Personal identity is composed of multiple facets of the self that are constructed and nourished through memories of past experiences (i.e., autobiographical memory) and the imagination of events that may occur in the future (i.e., future thinking) .

While our previous work has shown that people with relapsing-remitting multiple sclerosis (pwRRMS) have autobiographical memory and future thought disorders, their impact on personal identity has not yet been explored. Based on a cognitive and clinical neuropsychology approach, this research project aims to better understand the cognitive mechanisms involved in the relationship between identity, autobiographical memory and future thinking in pwRRMS. We will examine the extent to which pwRRMS manage to maintain and reshape their identity through life experiences, with a particular interest in the potential integration of the disease as a facet of their identity. In addition, we will explore the positive and/or negative consequences of disease-related identity changes on emotional well-being and quality of life, as well as their links with the duration and severity of the disease. Overall, this research project will contribute to identify new therapeutic levers that can be used for the development of adapted and personalized care.

Conditions

Multiple Sclerosis, Relapsing-Remitting; Healthy Controls

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Clinical group

45 individuals with relapsing-remitting multiple sclerosis

Neuropsychological tests and psychological questionnaires

Intervention Type: BEHAVIORAL

• The clinical group will complete:

• the BCcogSEP: a comprehensive neuropsychological examination
• the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity
• A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression
• The control group will complete:

• the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity
• A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression

Control group

45 individuals with no chronic disease, matched in age, gender and level of education

Neuropsychological tests and psychological questionnaires

Intervention Type: BEHAVIORAL

• The clinical group will complete:

• the BCcogSEP: a comprehensive neuropsychological examination
• the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity
• A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression
• The control group will complete:

• the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity
• A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression

Interventions

Neuropsychological tests and psychological questionnaires

• The clinical group will complete:

• the BCcogSEP: a comprehensive neuropsychological examination
• the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity
• A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression
• The control group will complete:

• the IAM and I WILL BE tasks; experimental neuropsychological tasks to assess autobiographical memory, future thinking and personal identity
• A series of questionnaires including the BRIEF COPE, the Connor Davidson Resilience Scale, the Satisfaction with Life Scale and the Hospital Anxiety and Depression Scale, which respectively assess coping strategies, resilience, life satisfaction and anxiety/depression

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Diagnosis of relapsing-remitting MS according to the McDonald's revised diagnostic criteria
• People aged between 18 and 55
• French native speaker
• Access to a computer or tablet, equipped with internet access, a camera and a microphone

• MS relapse in the month prior to the inclusion
• Treatment with corticosteroids during the month preceding the inclusion
• Form of MS other than the relapsing-remitting form
• Neurological history (other than MS for patients), history or current presence of psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia), substance abuse (e.g., alcohol, cannabis; past or present)
• Other diagnosed chronic pathology(ies) (other than MS for patients)
• Severe cognitive impairment
• Persons mentioned in Articles L1121-6 to L1121-8 in the French law (minors, persons deprived of liberty, adults subject to protective measures)

For the control group:

• People aged between 18 and 55
• Matched in age, gender and level in education
• French native speaker
• Access to a computer or tablet, equipped with internet access, a camera and a microphone

• Neurological history (other than MS for patients), history or current presence of psychiatric disorders (e.g., depression, anxiety disorders, schizophrenia), substance abuse (e.g., alcohol, cannabis; past or present)
• Other diagnosed chronic pathology(ies) (other than MS for patients)
• Severe cognitive impairment
• Persons mentioned in Articles L1121-6 to L1121-8 in the French law (minors, persons deprived of liberty, adults subject to protective measures)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Paris 8 Vincennes Saint Denis

OTHER

Sponsor Role: collaborator

ARSEP foundation

UNKNOWN

Sponsor Role: collaborator

Centre d'Investigation Clinique et Technologique 805

OTHER

Sponsor Role: lead

Responsible Party

Alexandra Ernst

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Alexandra ERNST, PhD

Role: PRINCIPAL_INVESTIGATOR

Laboratoire DysCo - Université Paris 8

Locations

Hopital Raymond Poincaré Garches

Garches, Hauts De Seine, France

Site Status: RECRUITING

Countries

France

Central Contacts

Alexandra Ernst, PhD

Role: CONTACT

aernst@univ-paris8.fr

+33628496210

Facility Contacts

Lucine Sonnet

Role: primary

lucine.sonnet@aphp.fr

01 47 10 46 14

Other Identifiers

2022-A00495-38

Identifier Type: -

Identifier Source: org_study_id