Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.

NCT ID: NCT05634655

Last Updated: 2022-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2025-01-01

Brief Summary

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DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.

Detailed Description

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Conditions

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Pituitary Tumors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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invasive PAs

no interventions between two groups

Intervention Type OTHER

no interventions between two groups

non-invasive PAs

no interventions between two groups

Intervention Type OTHER

no interventions between two groups

Interventions

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no interventions between two groups

no interventions between two groups

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 1\) histologically confirmed PAs, 2) Non-function pituitary adenomas

Exclusion Criteria

* 1\) Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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2ndAffiliated Hospital, School of Medicine

Hanzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wu Qun

Role: CONTACT

13605810393

Facility Contacts

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wu qun

Role: primary

13605810393

Other Identifiers

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2021-0765

Identifier Type: -

Identifier Source: org_study_id

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